| Tag | Content |
|---|
| CPLM ID | CPLM-012592 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
Protein Synonyms/Alias | NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 |
Gene Name | SLC9A3R2 |
Gene Synonyms/Alias | NHERF2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 291 | TEDGSAWKQDPFQES | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. |
Sequence Annotation | DOMAIN 11 90 PDZ 1.
DOMAIN 150 230 PDZ 2.
MOD_RES 183 183 Phosphoserine.
MOD_RES 254 254 Phosphoserine.
MOD_RES 272 272 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 337 AA |
Protein Sequence | MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN 60
GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ LTCTEEMAQR GLPPAHDPWE 120
PKPDWAHTGS HSSEAGKKDV SGPLRELRPR LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD 180
PGSPAARSGL RAQDRLIEVN GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR 240
VTPTEEHVEG PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL 300
HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF 337 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0005737; C:cytoplasm; IEA:Compara. GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; TAS:ProtInc. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara. GO:0006461; P:protein complex assembly; TAS:ProtInc. |
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PROSITE | |
PRINTS | |