UniProt Accession

 TRPE_YEAST; P00899; D3DLZ7 

Genbank Protein ID

 K01388; X68327; U18839; BK006939 

Genbank Nucleotide ID

 AAA35175.1; CAA48402.1; AAB64645.1; DAA07751.1 

Protein Name

 Anthranilate synthase component 1 

Protein Synonyms/Alias

 Anthranilate synthase component I 

Gene Name

 TRP2 

Gene Synonyms/Alias

 YER090W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
230	TFESNVGKEGYENHV	acetylation	[1]
368	PLTTSVDKLLTIQKF	ubiquitination	[2, 3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 MOD_RES 81 81 Phosphoserine.
 MOD_RES 223 223 Phosphothreonine.  

Keyword

 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; Lyase; Phosphoprotein; Reference proteome; Tryptophan biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0005950; C:anthranilate synthase complex; IPI:SGD.
 GO:0004049; F:anthranilate synthase activity; IDA:SGD.
 GO:0000162; P:tryptophan biosynthetic process; IMP:SGD. 

Interpro

 IPR005801; ADC_synthase.
 IPR019999; Anth_synth_I.
 IPR006805; Anth_synth_I_N.
 IPR005256; Anth_synth_I_PabB.
 IPR015890; Chorismate-bd_C. 

Pfam

 PF04715; Anth_synt_I_N
 PF00425; Chorismate_bind 

SMART

  

PROSITE

  

PRINTS

 PR00095; ANTSNTHASEI.