UniProt Accession

 HPF_ECOLI; P0AFX0; P31221; Q2M909 

Genbank Protein ID

 D12938; Z27094; U12684; U18997; U00096; AP009048 

Genbank Nucleotide ID

 BAA02316.1; CAA81618.1; AAB60164.1; AAA58005.1; AAC76235.1; BAE77247.1 

Protein Name

 Ribosome hibernation promoting factor 

Protein Synonyms/Alias

  

Gene Name

 hpf 

Gene Synonyms/Alias

 yhbH; b3203; JW3170 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
23	LREFVTAKFAKLEQY	acetylation	[1]
26	FVTAKFAKLEQYFDR	acetylation	[1]
42	NQVYVVLKVEKVTHT	acetylation	[1]
80	AIDGLIDKLARQLTK	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes. May convert immature 90S particles formed by RMF into 100S ribosomes. May also function as a potential translational inhibitor. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 95 AA 

Protein Sequence

Gene Ontology

 GO:0043024; F:ribosomal small subunit binding; IDA:EcoCyc.
 GO:0043022; F:ribosome binding; IDA:EcoCyc.
 GO:0017148; P:negative regulation of translation; IDA:EcoCyc.
 GO:0044238; P:primary metabolic process; IEA:InterPro. 

Interpro

 IPR003489; Ribosomal_S30Ae/sigma54_mod. 

Pfam

 PF02482; Ribosomal_S30AE 

SMART

  

PROSITE

  

PRINTS