UniProt Accession

 RABP2_HUMAN; P29373; B2R4Z8; D3DVC5; F1T098; Q6ICN6 

Genbank Protein ID

 M68867; M97815; M97814; CR450357; BT019827; AK312007; AB593017; AL590666; CH471121; CH471121; BC001109 

Genbank Nucleotide ID

 AAA52068.1; AAA58430.1; AAA58430.1; CAG29353.1; AAV38630.1; BAG34945.1; BAJ83972.1; CAI16339.1; EAW52921.1; EAW52922.1; AAH01109.1 

Protein Name

 Cellular retinoic acid-binding protein 2 

Protein Synonyms/Alias

 Cellular retinoic acid-binding protein II; CRABP-II 

Gene Name

 CRABP2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	ENFEELLKVLGVNVM	ubiquitination	[1, 2]
31	GVNVMLRKIAVAAAS	ubiquitination	[1, 2]
39	IAVAAASKPAVEIKQ	ubiquitination	[1, 2, 3]
45	SKPAVEIKQEGDTFY	ubiquitination	[1, 2]
83	TVDGRPCKSLVKWES	ubiquitination	[4, 5]
87	RPCKSLVKWESENKM	ubiquitination	[1]
102	VCEQKLLKGEGPKTS	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. 

Sequence Annotation

 REGION 133 135 Retinoic acid binding.
 MOTIF 21 31 Nuclear localization signal.
 CROSSLNK 102 102 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endoplasmic reticulum; Isopeptide bond; Nucleus; Reference proteome; Retinol-binding; Transport; Ubl conjugation; Vitamin A. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 138 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
 GO:0001972; F:retinoic acid binding; IEA:Compara.
 GO:0005501; F:retinoid binding; TAS:ProtInc.
 GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0008544; P:epidermis development; TAS:ProtInc.
 GO:0006355; P:regulation of transcription, DNA-dependent; TAS:ProtInc.
 GO:0042573; P:retinoic acid metabolic process; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00214; FABP 

PRINTS

 PR00178; FATTYACIDBP.