CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022786
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-iminoacetate synthase 
Protein Synonyms/Alias
 Dehydroglycine synthase; Tyrosine lyase 
Gene Name
 thiH 
Gene Synonyms/Alias
 STM4159; STMF1.38 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
119RECDAIRKLGFEHLLacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol. 
Sequence Annotation
 METAL 85 85 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 METAL 89 89 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 METAL 92 92 Iron-sulfur (4Fe-4S-S-AdoMet) (By  
Keyword
 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Thiamine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MKTFTDRWRQ LEWDDIRLRI NGKTAADVER ALNAAHLSRD DLMALLSPAA ADYLEPIAQR 60
AQRLTRQRFG NTVSFYVPLY LSNLCANDCT YCGFSMSNRI KRKTLDEVDI QRECDAIRKL 120
GFEHLLLVTG EHQAKVGMDY FRRHLPTIRR QFSSLQMEVQ PLSQENYAEL KTLGIDGVMV 180
YQETYHEAIY AQHHLKGKKQ DFFWRLETPD RLGRAGIDKI GLGALIGLSD NWRVDCYMVA 240
EHLLWMQKHY WQSRYSVSFP RLRPCTGGVE PASVMDEKQL VQTICAFRLL APEIELSLST 300
RESPWFRDHV IPLAINNVSA FSKTQPGGYA DDHPELEQFS PHDARRPETV ASALSAQGLQ 360
PVWKDWDSWL GRASQTR 377 
Gene Ontology
 GO:0036355; F:2-iminoacetate synthase activity; IEA:EC.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR010722; Biotin/thiamin_synth-assoc.
 IPR007197; rSAM.
 IPR012726; ThiH. 
Pfam
 PF06968; BATS
 PF04055; Radical_SAM 
SMART
 SM00876; BATS 
PROSITE
  
PRINTS