UniProt Accession

 RGDSR_HUMAN; Q8IZJ4 

Genbank Protein ID

 AY101396; AP000347 

Genbank Nucleotide ID

 AAM51551.1 

Protein Name

 Ral-GDS-related protein 

Protein Synonyms/Alias

 hRGR; Ral guanine nucleotide dissociation stimulator-like 4; RalGDS-like 4 

Gene Name

 RGL4 

Gene Synonyms/Alias

 RGR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
340	TWAGVSSKSMKELKE	acetylation	[1]
343	GVSSKSMKELKELCK	acetylation	[1]
417	DLDGNTNKRSKEVRV	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 DOMAIN 219 471 Ras-GEF.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Guanine-nucleotide releasing factor; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 473 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 

Pfam

 PF00617; RasGEF 

SMART

 SM00147; RasGEF 

PROSITE

 PS00720; RASGEF
 PS50009; RASGEF_CAT 

PRINTS