UniProt Accession

 ATP5E_YEAST; P21306; D6W399 

Genbank Protein ID

 X64767; Z73627; AY558140; BK006949 

Genbank Nucleotide ID

 CAA46014.1; CAA98007.1; AAS56466.1; DAA11165.1 

Protein Name

 ATP synthase subunit epsilon, mitochondrial 

Protein Synonyms/Alias

 ATPase subunit epsilon 

Gene Name

 ATP15 

Gene Synonyms/Alias

 YPL271W; P0345 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
27	QAIRSSLKTELQTAS	acetylation	[1]
49	DAFYTQYKNGTAASE	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 

Sequence Annotation

 MOD_RES 52 52 Phosphothreonine.  

Keyword

 3D-structure; ATP synthesis; CF(1); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Hydrolase; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 62 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005756; C:mitochondrial proton-transporting ATP synthase, central stalk; IDA:SGD.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IDA:GOC.
 GO:0015986; P:ATP synthesis coupled proton transport; IDA:SGD. 

Interpro

 IPR006721; ATPase_F1-cplx_esu_mt. 

Pfam

 PF04627; ATP-synt_Eps 

SMART

  

PROSITE

  

PRINTS