CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fanconi anemia-associated protein of 100 kDa 
Protein Synonyms/Alias
  
Gene Name
 Faap100 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
454ANAGQKIKELLLDIGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 879 AA 
Protein Sequence
MAGASSRVHY LSDFCCPLGG RAAGKPFVLR HEAEVFLSTG REFVYVYDQE GGLLTAVYQF 60
PDQVWHLQLL AIRRALYVLC ARTGIYCLSL DSLDRSGSQA CEDKEEAAPP YPVIHVDPDA 120
CVLPDAALCA FTVLDDMLVT LAQGPTQWKM QLFERPCAGE EPLPRGQIGE VELSTCTPPG 180
GVPEKPAAPR FLPVLCCVFP PDSRAPHGHP QGCGCFTLEE ALFGLLFGVD ATLLQSPVIL 240
CGLPDGQLCC VVLKALVTSG LAPGDPKVLV KILHHLEEPV IFIGALRAEP HEEEAAGELL 300
PGQHEHSDCL VALGHQGRTL AIKASWSESG NLVPELREYC LPGPVLCAAC DRDGHVYHST 360
PSDLCVVDLT RRDSPWNPEK PDGAIGGLPS VLCPASLNIC SALALCVTAR APTGSTELLA 420
LSSKGRLITC SLDLNSEAPV PAKMAMANAG QKIKELLLDI GDVSERVSFL KKAVDQRNKA 480
ITSLNEAMNV SCALLSHPEG DRPIACTITT SWSRLELRDM LMATCTLENS SSFSLDQGWT 540
LCIQVLTSSS ALDLDGTGSA FTYTIPVDRL GPGSRREVTL PLGPSESGVL DLPVTMSCWL 600
FYSLREVVGA ALAPSDPLEA PYLEQFPLSL PKQEGVCLPL CKRTVDMLQC LRFAGAATHP 660
AQAPCMPGPA CEPVETFLKT CQAPGSEPTG AASLRAKYLP PSTASIRVSA GLLRAALEDS 720
HSGFHLCSAT LRWLLAENAA VDVVRAQTLS SIQGIAPDGT DVNLTVHEVA VTDLSPAGPI 780
QAVEIQVESS SLANMCRAHH AIIRRIQTMV TEQAALGSSP PDLRMQYLQQ IHANHQELLR 840
EVQALRDQLC TEDELSSCST AQKLLHIYKQ LRNPSLVLL 879 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS