CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039545
UniProt Accession
Genbank Protein ID
 U47924 
Genbank Nucleotide ID
  
Protein Name
 Prohibitin-2 
Protein Synonyms/Alias
  
Gene Name
 PHB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
236YTAAVEAKQVAQQEAacetylation[1]
236YTAAVEAKQVAQQEAubiquitination[2, 3, 4, 5]
252RAQFLVEKAKQEQRQacetylation[1, 5]
252RAQFLVEKAKQEQRQubiquitination[2, 4]
254QFLVEKAKQEQRQKIubiquitination[5, 6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI FFNRIGGVQQ 60
DTILAEGLHF SGCCENLQQH TNCCFPEGQE NLSLSVVVER SRPKNAWIPW FQYPIIYDIR 120
ARPRKISSPT GSKDLQMVNI SLRVLSRPNA QELPSMYQRL GLDYEERVLP SIVNEVLKSV 180
VAKFNASQLI TQRAQVSLLI RRELTERAKD FSLILDDVAI TELSFSREYT AAVEAKQVAQ 240
QEAQRAQFLV EKAKQEQRQK I 261 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro. 
Interpro
 IPR001107; Band_7.
 IPR000163; Prohibitin. 
Pfam
 PF01145; Band_7 
SMART
 SM00244; PHB 
PROSITE
  
PRINTS
 PR00679; PROHIBITIN.