CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Dst 
Protein Synonyms/Alias
  
Gene Name
 Dst 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1408EKSLDEEKKQHVEKAubiquitination[1]
5470EVLIIQDKLEAIKARacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 7350 AA 
Protein Sequence
DERDKVQKKT FTKWINQHLM KVRKHVNDLY EDLRDGHNLI SLLEVLSGDT LPREKGRMRF 60
HRLQNVQIAL DYLKRRQVKL VNIRNDDITD GNPKLTLGLI WTIILHFQIS DIHVTGESED 120
MSAKERLLLW TQQATEGYAG VRCENFTTCW RDGKLFNAII HKYRPDLIDM NTVAVQSNLA 180
NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE KSVITYVSSL YDAFPKVPEG GEGIGANDVE 240
VKWIEYQNMV NYLIQWIRHH VVTMSERTFP NNPLELKALY NQYLQFKEKE IPPKETEKSK 300
IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK EWGKLIIAML EREKALRPEV ERLDMLQQIA 360
TRVQRDSVSC EDKLMLARNA LQSDSKRLES GVQFQNEAEI AGYILECENL LRQHVIDVQI 420
LLDGKYYQAE QLVQRVAKLR DEILALRNEC SAVYSKGRML TTEQTKLMIS GITQSLNSGF 480
AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS SGMTSRLTPS VTPAYTPGFP SVVAPNFSVG 540
VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD 600
LPSVESHLEN HKNVHRAIEE FESSLKEAKI SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT 660
SRNQERHLDT LHNFVTRATN ELIWLNEKEE SEVAYDWSER NSNVARKKGY HAELMRELEQ 720
KEESIKAVQE IAEQLLLESH PARLTIEAYK AAMQTQWSWI LQLCQCVEQH IQENTAYFEF 780
FNDAKEATDY LRNLKDAIQR KYVCDRSSSI RKLEDLVQES MEKEELLQYR SVVAGLMGRA 840
KTVVQLKPRN PDNPLKTSIP IKAICDYRQI EITIYKDDEC VLANNSHRAK WKVISPTGNE 900
AMVPSVCFTV PPPNKEAVDF ANRIEQQYQS VLTLWHESHV NMKSIVSWHY LVNEIDRIRA 960
SNVASIKTML PGEHQQVLSN LQSRLEDFLE DSQESQIFSG SDITQLEKEV NVCRKYYQEL 1020
LKSAEREEQE ESVYNLYVSE VRNIRLRLES CEDRLIRQIR TPLERDDLHE SMLRITEQEK 1080
LKKELERLKD DLEAITNKCE EFFSQAADSP SVPALRSELS VVLQSMSQIY SMSATYVEKL 1140
KTVNLVLKNT QAAEALVKLY ETKLCEEEAV IADKNNIENL MSTLKQWRSE VDEKREVFHA 1200
LEDELQKAKA ISDEMFKTHK ERDLDFDWHK EKADQLVERW QSVHVQIDNR LRDLEGIGKS 1260
LKHYRDSYHP LDDWIQQIET TQRKIQENQP ENSKALAVQL NQQKMLVSEI EVKQSKMDEC 1320
QKYSEQYSAA VKDYELQTMT YRAMVDSQQK SPMKRRRIQS SADLIIQEFM DLRTRYTALV 1380
TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ HVEKAKELQK WVSNISETLG DGERAGKPHF 1440
SKQQISSKEI SAKKEQFSEA LQNTQIFLAK HGDKLTEEDR SDLEKQVKTL QEGYNLLFSE 1500
SLKQQELQPS GEAKVKVEEK PDKVIAGTIN QTTGEVLSVF QAVLRGLIDY ETGIRLLEAQ 1560
LVISGLISPE LRKCFDLKDA ERHGLVDEQI LGQLKELNEA KQIISTASPT MIPVLDSLDR 1620
GVISESVAIR VLEILLSTDS LVVPATGEHL TLQKAFQQNL ISSALFSKVL ERQAACKDLI 1680
DPCTSEKVSL TDMVQRSILQ ENTRMWLLPV RPQEAGRITL KCGRSVSILR AAHEGIIDRE 1740
TMFRLLGAQL LSGGLVDCNS GQKMTVEEAL AEGVIDRDTA SSILTYQVRT GGILHSNPAK 1800
RLTVDEAVQC ELITSSSALL VLEAQRGYVG LIWPHSGEIF PTASSLEQEL ITNELACKIL 1860
NGRQKIAALY FPETSQVIDL DAARRLGIID NNTASVLKHV TLPDKMPDLG DLEACKNARK 1920
WLSFCKFQPS TAHHYTQEED GSDGDEPVAA QSSEQTKKLF LSYLMVNSYM DANTGRRLLL 1980
HDGDLEEAVG MLLESCGAEL GAGTAVRESL SVLPVPDASP DCASSREKHG CSTLAAGSDK 2040
CHYRHPGHKG PLENAKWDLN GELCEMGNNE DSGELPRLEN LTDTTVAQKA GGPSSVRVPK 2100
PTSYSTQPEL KNQSELDTEA SPDEGIHSGV CTSETSRLCD ASETEDEDHI QKGPSVFDYS 2160
PRLSALLSHD LLRHSQGSFS DTPKNTGYLC EASTLSSGDQ SVLADQSTGE KLQDQFLGIA 2220
AISVSLQGAP CGQTPVDNGC SNCQVHYSSD EYMSDASAES GTTRQTSETE KTGSEVEDDS 2280
CTMIPGDGSC NANPSACRPL SLKGAIDAGD YETSLLAGQQ SDTATDSDSD DYFYDTPLFE 2340
DEDHDSLILQ GDDHDCLQPE DYDTLQEEND KTPPPDDIFY DVLKENENPE SSPGGMDESL 2400
SAGGKVHFPQ GFLVGTKRPE LYVVDQKQFN LGDSDKMRER LAEPVPESET PSDLEHSESD 2460
SLTDGEITGR KESLGTSVTP GGRWRGDREE CDTSQESQSD TDGVGFVQSI ESSRLYMSDG 2520
SDRDEEDNGT YSSEDDDDRG GGGQEVAGEN GEPSDPASHN QLYTATVKES GAETQSVRDT 2580
ILLDRMHGYS PLEKQQRGRV LQPESAGKRG RDTERSNHPE LTTEADEEDR ASVSTHMATT 2640
GVSLSNAQGT ASENVELVQG PGSTDILKDE DEYLENGSPK NGQPSNKIVC SEAGLGGGPS 2700
EESHLSFTVS NRGQRGTGRG QVKGRDGKNS QGVGEMSIQE TGFREDGGLM SSPEEGEEER 2760
CLNPFPNGIA TGSPNTGESL FTPLLTHTEE LRHRGDPNTA TMTLDCEAKD GQTGLRESPV 2820
LLETLAEIFD TSASKETHAD PTSALRSSGV KSQVKEDSLT GGSEKETGPF TSPERCDKCV 2880
NVDVLESNKH TPSCAFIASP PMKDDLPTVT NAEEKPVIPQ GDWPSGAKIQ PSGACVKGSM 2940
SEGKAGIPHF TPEHSDTTLS LLPQKSVAEC GGNTDFVQAQ LHMNGVRNTS DNTLDVGCPR 3000
LESSREKERT EKQPHGERTS SPRPQERVHT PEFGEDGGTL KSGLDKVQMN LQDVGDPSAC 3060
TGTTISIQNL IKRAILSELP NETSNVPSPG VSPINNSSEE KAENRGDPLC IASLLEILKQ 3120
DQHTQETPGT SELIKVLTQT ACNPEERGLV SGLFPPQLKN VFCKLLLDGY SAEREQAEAL 3180
KQTPGAAPEM VEEKPCDCSD LKSKEGNHYT PNPQTVREAG VEHSGVHTAA LPRDEEFGEL 3240
CSEPPDHSEC TSGSKEISSD DNTKEKCSNG LQQCLQHTEK MHEYLALLQD MKPPLDNQAA 3300
MENSLEALKN QLKQLETFEL GLAPMAVFLR KDLKLAEEFL KSFPSDLPGR HHEELSKSHE 3360
RLQNAFESLS SVSSQRMKLI TLAIDTETSK LAVRHEDFLH RLTSYSDWVS EKSRSVADIQ 3420
TVNVQDTELV KNSVKFLKAR NVLTDLSHTK VQLETTAFDI QSFISDYAQD LSPNQSRQLL 3480
RLLNTTQKCF LDVQELVTSE VVRLETLLQL EQELGHQKVV AERQQEYKEK LQGLCDLLTQ 3540
TENRLISHQE TFVIGDGTVE LKKYQSKQEE LQRDMQGSTQ ALAEIVRNTE IFLKESGDEL 3600
SQEDKALIEQ KLNEAKVKCE QLNLKAEQST KELDKVVTAA LKEETEKVAA ARQLEESKTK 3660
IENLLNWLSN VEKDSEGSGR LHTQPLEQNG THLHEGDGTS EAGEEDEVNG NLLETDAEGH 3720
GGMTEGNLNQ QYEKVKAQHE KIVAQHQAVI MATQSAQALL EKQGHHLSPE EKEKLQANVQ 3780
ELKAHYETVL AECEKKVKLT HSLQEELEKF DADCGEFEHW LQQSEQELEN LEAGADDLSG 3840
LTDKLARQKS FSEDVISHKG DLRYITISGN RVMEAAKSCS KRDGDRIGKD SLETSATHRE 3900
VQTKLDQVTD RFRCLYSKCS VLGNNLKDLV DKYQHYEDAS CGLLSGLQAC EAKASRHLLE 3960
PIALDPKNLQ RQLEETKALQ GQISSQQAAV EKLKKTAEVL LDAKGSLLPA KNDIQKTLDD 4020
IVGRYDDLSK SVNERNEKLQ ITLTRSLSVQ DGLDEMLDWM GSVESSLVKQ GQVPLNSTAL 4080
QDLISKNIML DQDITGRQSS INAMNEKVKT FIETTDPSTA SSLQAKMKDL SARFSEASQK 4140
HKEKLAKMVE LKSKVEEFEK LSDKLQTFLE TQSQALTEVD MPGKDVPELS QHMQESTTKF 4200
LEHRKDLEAL HSLLKEISSH GLPGDKALVF EKTNNLSKKF KELEDTIQEK KEALSSCQEQ 4260
LSAFHDLAQS LKTWIKETTK QVPIVKPSFG TEDLEKSLEE TKKLQEKWSL KTPEIHKANN 4320
SGVSLCNLLS ALISPAKAIA AARSGGVILN GEGTDTNTQD FLANKGLTSI KTDMTDISHS 4380
YEDLGLLLKD KIVELNTKLS KLQKAQEESS AMMQWLQKMN KTASRWRQTP TPADSESVKI 4440
QVEQNKSFEA ELKQNVNKVQ ELKDKLAELL KENPEAPEAP SWKQTMAEMD TKWQELNQLT 4500
IDRQQKLEES SNNLSQFQTT EAQLKQWLVE KELMVSVLGP LSTDPNMLNT QKQQAQILLQ 4560
EFDTRKPQYE QLTAAGQGIL SRPGEDPSLH GIVKEQLAAV TQKWDNLTGQ LRDRCDWIDQ 4620
AIVKSTQYQS LLRSLSGTLT ELDEKLSSSL ISGTLPDAVN QQLEAAQKLK QEIEQQTPKI 4680
KEAQTLCEDL SALVKEEYLR AELSRQLEGV LKSFKDIEQK TENHVQHLQS ACASSHQFQQ 4740
MSKDFQAWLD AKKEEQRNSP PISAKLDVLE SLLKAQKDFG KTFTEQSNIY EKTVAEGENL 4800
LSKTQGAEKA ALQLQLNTIK TDWDRFRKQV KEREEKLKES LEKALRYREQ VDTLQPWVDK 4860
CQHSLESVKL SLDPADTERS ITELKTLQKE MDHHFGTLEL LNNSANSLLS VCEVDKEVVT 4920
EGNKSLIQKV NVVTEQLQSK KVSLENMAQK FKEFQEVSKD AKRQLQDTKE QLEVYQSLGP 4980
QACSNKHLTM LQAQQKSLQT LKHQVDSARR LAQDLVMEAT DPKGTSDVLS QAETLAEEHR 5040
GLSQQVDEKC SFLETKLQGL GHFQNTIREM FSQFTEFDDE LDSMAPVGRD VETLQKQKAS 5100
MQTFLKKLEA LITSNDSANR TCKMMLATEE TSPDLIGVKR DLEALSKQCN KLLDRAKTRE 5160
EQVSGATEKL EEFHRKLEEF STLLQKAEEH EESQGPVGTE TDAINQQLDV FKIFQKEEIE 5220
PLQAKQQDVN WLGQGLIQSA AANTCTQGLE HDLDSINARW KTLNKKVAQR TSQLQEALLH 5280
CGRFQDALES LLSWMADTEE LVANQKPPSA EFKVVKAQIQ EQKLLQRLLE DRKSTVEAIK 5340
REGEKIAASA EPADRVKLSR QLSLLDSRWE MLLSRAEARN RQLEGISVVA QEFHETLEPL 5400
NEWLTAVEKK LANSEPIGTQ APKLEEQIAQ HKALQEDILL RKQSVDQALL NGLELLKQTT 5460
GDEVLIIQDK LEAIKARYKD ITKLSADVAK TLEHALQLAG QLQSKHKELC NWLDRVEVEL 5520
LSYETQGLKG EAASQVQERQ KELKNEVRNN KALLDSLNEV SSALLELVPW RAREGLEKTV 5580
AEDNERYRLV SDTITQKVEE IDAAILRSQQ FDQAADAELS WITETQKKLM SLGCIRLEQD 5640
QTSAQLQAQK AFTMDILRHK DIIDELVTSG HKIMTTSSEE EKQSMKKKLD KVLKKYDAIC 5700
QINSERHLQL ERAQSLVSQF WETYEELWPW LMETQQIISQ LPAPALEYET LRRQQEEHRQ 5760
LRELIAEHKP HIDKMNKTGP QLLELSPKEG VHIQEKYVAA DTLYSQIKED VKKRAVVLDE 5820
AISQSTQFHD KIDQILESLE RIAERLRQPP SISAEVEKIK EQIGENKSVS VDMEKLQPLY 5880
ETLRQRGEEM IARSEGTEKD ISAKAVQDKL DQMVFIWGSI HTLVEDREAK LLDVMELAEK 5940
FWCDHMSLVV TTKDTQDFIR DLEDPGIDPS VVKQQQEAAE AIREEIDGLQ EELDMVITLG 6000
SELIAACGEP DKPIVKKSID ELNSAWDSLN KAWKDRIDRL GEAMQAAVQY QDGLQAIFDW 6060
VDIAGNKLAT MSPIGTDLET VKQQIEELKQ FKSEAYQQQI EMERLNHQAE LLLKKVTEEV 6120
DKHTVQDPLM ELKLIWDSLD ERIVSRQHKL EGALLALGQF QHALDELLAW LTHTKGLLSE 6180
QKPVGGDPKA IEIELAKHHV LQNDVLAHQS TVEAVNKAGN DLIESSEGEE ASNLQYKLRI 6240
LNQRWQDILE KTDQRKQQLD SALRQAKGFH GEIEDLQQWL TDTERHLLAS KPLGGLPETA 6300
REQLNAHMEV CTAFAIKEET YKNLMLRGQQ MLARCPRSVE TNIDQDITNL KEKWESVKSK 6360
LNEKKTKLEE ALHLAMEFHN SLQDFINWLT QAEQTLNVAS RPSLILDTIL FQIDEHKVFA 6420
NEVNSHREQI IELDKTGTHL KYFSQKQDVV LIKNLLISVQ SRWEKVVQRL VERGRSLDEA 6480
RKRAKQFHEA WSKLMEWLED SEKSLDSELE IANDPDKIKA QLVQHKEFQK SLGGKHSVYD 6540
TTNRTGRSLK EKTSLADDTL KLENMLSELR DKWDTICGKS VERQNKLEEA LLFSGQFTDA 6600
LQALIDWLYR VEPQLAEDQP VHGDIDLVMN LIDNHKVFQK ELGKRTSSVQ ALKRSARELI 6660
EGSRDDSSWV RVQMQELSTR WETVCALSIS KQTRLESALQ QAEEFHSVVH TLLEWLAEAE 6720
QTLRFHGALP DDEDALRTLI EQHKEFMKKL EEKRAELNKA TGMGDALLTA CHPDSITTIK 6780
HWITIIQARF EEVLAWAKQH QQRLAGALAG LIAKQELLEN LLAWLQWAET TLTEKDKEVI 6840
PQEIEEVKTL IAEHQTFMEE MTRKQPDVDK VTKTYKRRAA DPPSLQSHIP VLDKGRAGRK 6900
RFPASGLYPS GSQTQIETKN PRANLLVSKW QQVWLLALER RRKLNDALDR LEELREFANF 6960
DFDIWRKKYM RWMNHKKSRV MDFFRRIDKD QDGKITRQEF IDGILSSKFP TSRLEMSAVA 7020
DIFDRDGDGY IDYYEFVAAL HPNKDAYKPI TDADKIEDEV TRQVAKCKCA KRFQVEQIGD 7080
NKYRVSKEKQ FFGDSQQLRL VRILRSTVMV RVGGGWMALD EFLVKNDPCR VHHHGSKMLR 7140
SESNSSITAT QPTLAKGRTN MELREKFILA DGASQGMAAF RPRGRRSRPS SRGASPNRST 7200
SASSHACQAA SPQVPAAAST PKGTPIQGSK LRLPGYLSGK GFHSGEDNAL ITTAASRVRT 7260
QFAESRKTPS RPGSRAGSKA GSRASSRRGS DASDFDISEI QSVCSDVETV PQTHRPAPRA 7320
GSRPSTAKPS KIPTPQRKSP ASKLDKSSKR 7350 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR003108; GAS2_dom.
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF13499; EF_hand_5
 PF02187; GAS2
 PF00681; Plectin
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00054; EFh
 SM00243; GAS2
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51460; GAR 
PRINTS