CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036424
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase RNF8 
Protein Synonyms/Alias
  
Gene Name
 Rnf8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
547REGEGLGKYSQGRKDacetylation[1]
642LHSMLKCKSVFDILDubiquitination[2]
678FLNRAAMKMANMDFVubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 719 AA 
Protein Sequence
MGEPDPLVSG QLAARRSWCL RRLGMDCEWL QLEAGTEVTI GRGLSVTYQL ISKVCPLMIS 60
RSHCVLKQNP EGQWTIMDNK SLNGVWLNRE RLAPLQGYCI RKGDHIQLGV PLESRETAEY 120
EYEVIEEDWE SLAPCLAPKN DQRMEKHKGS RTKRKFSSPG LENLPAEGSS DLRCPLANVA 180
SKPIEPEKLH GKGDASSQSL GCLCPGLTSL KASERAAGPH ACSALPKVLE LSCPKKQKAC 240
RPSASQNSLE LFKVTMSRML KLKTQMQEKQ IAVLNVKRQT RKGSSKKIVR MEKELRNLQS 300
QLYAEQAQQQ ARVEQLEKTF QEEAHYLQGL EKEQGECDLK QQLVQALQEH QALMEELNCS 360
KKDFEKIIQA KNKELEQTKE EKDKVQAQKE EVLSHMNDLL ENELQCIICS EYFIEAVTLN 420
CAHSFCSFCI NEWMKRKVEC PICRKDIESR TNSLVLDNCI SKMVDNLSSD VKERRSVLIR 480
ERRASATSLS GSDSETEGKQ PCSDDFKDAF KADSLVEGTS SRYSMYNSVS QRLMAKMGFR 540
EGEGLGKYSQ GRKDIVETSN QKGRRGLGLT LQGFDQELNV DWRDEPEPNA CEQVSWFPEC 600
TTEIPDSREM SDWMVVGKRK MVIEDETEFC GEELLHSMLK CKSVFDILDG EEMRRARTRA 660
NPYEMIRGVF FLNRAAMKMA NMDFVFDRMF TNPLDSSGAR EASPSTCCGG RSGTQRALG 719 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051301; P:cell division; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:InterPro.
 GO:0006974; P:response to DNA damage stimulus; IEA:InterPro. 
Interpro
 IPR017335; E3_Ub_ligase_RNF8.
 IPR000253; FHA_dom.
 IPR000467; G_patch_dom.
 IPR008984; SMAD_FHA_domain.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00498; FHA
 PF01585; G-patch 
SMART
 SM00240; FHA
 SM00443; G_patch
 SM00184; RING 
PROSITE
 PS50006; FHA_DOMAIN
 PS50174; G_PATCH
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS