UniProt Accession

 H2B10_ARATH; Q9FFC0; Q96516 

Genbank Protein ID

 Y07745; AB005243; CP002688 

Genbank Nucleotide ID

 CAA69025.1; BAB10609.1; AED93093.1 

Protein Name

 Histone H2B.10 

Protein Synonyms/Alias

 HTB2 

Gene Name

 At5g22880; MRN17.11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
6	**MAKADKKPAEKKP	acetylation	[1]
11	ADKKPAEKKPAEKTP	acetylation	[1]
12	DKKPAEKKPAEKTPA	methylation	[2]
16	AEKKPAEKTPAAEPA	acetylation	[1]
28	EPAAAAEKKPKAGKK	acetylation	[1]
34	EKKPKAGKKLPKEPA	acetylation	[1]
35	KKPKAGKKLPKEPAG	acetylation	[1]
67	IYIFKVLKQVHPDIG	methylation	[2]
78	PDIGISSKAMGIMNS	methylation	[2]
129	VLPGELAKHAVSEGT	methylation	[2]

Reference

 [1] Characterization of post-translational modifications of histone H2B-variants isolated from Arabidopsis thaliana.
 Bergmüller E, Gehrig PM, Gruissem W.
 J Proteome Res. 2007 Sep;6(9):3655-68. [PMID: 17691833]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 11 11 N6-acetyllysine.
 MOD_RES 12 12 N6,N6-dimethyllysine.
 MOD_RES 16 16 N6-acetyllysine.
 MOD_RES 28 28 N6-acetyllysine.
 MOD_RES 34 34 N6-acetyllysine.
 MOD_RES 35 35 N6-acetyllysine; partial.
 CROSSLNK 141 141 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:TAIR.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.