| Tag | Content |
|---|
| CPLM ID | CPLM-011894 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kinesin-like protein KIF1A |
Protein Synonyms/Alias | Axonal transporter of synaptic vesicles; Microtubule-based motor KIF1A; Unc-104- and KIF1A-related protein; hUnc-104 |
Gene Name | KIF1A |
Gene Synonyms/Alias | ATSV; C2orf20 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 201 | DLMDSGNKARTVAAT | ubiquitination | [1] | | 679 | QRLDYESKLEALQKQ | ubiquitination | [2] | | 685 | SKLEALQKQMDSRYY | ubiquitination | [1] | | 1011 | VRQSGTAKISFDDQH | ubiquitination | [1] | | 1140 | AFSTEPLKNTGRGPP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity). |
Sequence Annotation | DOMAIN 1 361 Kinesin-motor.
DOMAIN 516 572 FHA.
DOMAIN 1575 1673 PH.
NP_BIND 97 104 ATP (By similarity).
MOD_RES 416 416 Phosphoserine.
MOD_RES 418 418 Phosphoserine.
MOD_RES 419 419 Phosphoserine.
MOD_RES 937 937 Phosphoserine.
MOD_RES 1310 1310 Phosphoserine.
MOD_RES 1548 1548 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Hereditary spastic paraplegia; Mental retardation; Microtubule; Motor protein; Neurodegeneration; Neuropathy; Nucleotide-binding; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1690 AA |
Protein Sequence | MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 60
SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 120
QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 180
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 240
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 300
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI 360
NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDTNTVPGG PKLTNALVGM SPSSSLSALS 420
SRAASVSSLH ERILFAPGSE EAIERLKETE KIIAELNETW EEKLRRTEAI RMEREALLAE 480
MGVAMREDGG TLGVFSPKKT PHLVNLNEDP LMSECLLYYI KDGITRVGRE DGERRQDIVL 540
SGHFIKEEHC VFRSDSRGGS EAVVTLEPCE GADTYVNGKK VTEPSILRSG NRIIMGKSHV 600
FRFNHPEQAR QERERTPCAE TPAEPVDWAF AQRELLEKQG IDMKQEMEQR LQELEDQYRR 660
EREEATYLLE QQRLDYESKL EALQKQMDSR YYPEVNEEEE EPEDEVQWTE RECELALWAF 720
RKWKWYQFTS LRDLLWGNAI FLKEANAISV ELKKKVQFQF VLLTDTLYSP LPPDLLPPEA 780
AKDRETRPFP RTIVAVEVQD QKNGATHYWT LEKLRQRLDL MREMYDRAAE VPSSVIEDCD 840
NVVTGGDPFY DRFPWFRLVG SSAISGCNSY PLLNTCMSER MAALTPSPTF SSPDSDATEP 900
AEEQSVGEEE EEEEEEEDEE EEDLEDDVFP EHALCDGRDP FYDRPPLFSL VGRAFVYLSN 960
LLYPVPLVHR VAIVSEKGEV KGFLRVAVQA ISADEEAPDY GSGVRQSGTA KISFDDQHFE 1020
KFQSESCPVV GMSRSGTSQE ELRIVEGQGQ GADVGPSADE VNNNTCSAVP PEGLLLDSSE 1080
KAALDGPLDA ALDHLRLGNT FTFRVTVLQA SSISAEYADI FCQFNFIHRH DEAFSTEPLK 1140
NTGRGPPLGF YHVQNIAVEV TKSFIEYIKS QPIVFEVFGH YQQHPFPPLC KDVLSPLRPS 1200
RRHFPRVMPL SKPVPATKLS TLTRPCPGPC HCKYDLLVYF EICELEANGD YIPAVVDHRG 1260
GMPCMGTFLL HQGIQRRITV TLLHETGSHI RWKEVRELVV GRIRNTPETD ESLIDPNILS 1320
LNILSSGYIH PAQDDRVSLG NDTRTFYQFE AAWDSSMHNS LLLNRVTPYR EKIYMTLSAY 1380
IEMENCTQPA VVTKDFCMVF YSRDAKLPAS RSIRNLFGSG SLRASESNRV TGVYELSLCH 1440
VADAGSPGMQ RRRRRVLDTS VAYVRGEENL AGWRPRSDSL ILDHQWELEK LSLLQEVEKT 1500
RHYLLLREKL ETAQRPVPEA LSPAFSEDSE SHGSSSASSP LSAEGRPSPL EAPNERQREL 1560
AVKCLRLLTH TFNREYTHSH VCVSASESKL SEMSVTLLRD PSMSPLGVAT LTPSSTCPSL 1620
VEGRYGATDL RTPQPCSRPA SPEPELLPEA DSKKLPSPAR ATETDKEPQR LLVPDIQEIR 1680
VSPIVSKKGY LHFLEPHTSG WARRFVVVRR PYAYMYNSDK DTVERFVLNL ATAQVEYSED 1740
QQAMLKTPNT FAVCTEHRGI LLQAASDKDM HDWLYAFNPL LAGTIRSKLS RRRSAQMRV 1799 |
Gene Ontology | |
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PROSITE | |
PRINTS | |