CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019383
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neuralized-like protein 4 
Protein Synonyms/Alias
  
Gene Name
 NEURL4 
Gene Synonyms/Alias
 KIAA1787 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
530FHPNCGQKAAITHEGubiquitination[1]
633GHNLDRLKAGDTVGVubiquitination[1, 2]
768LFEIVIQKMVDRWSGubiquitination[1]
841IGMMRTAKGDLHYFIubiquitination[3, 4]
966KVEELDEKWAGSLRLubiquitination[1, 5]
1232NGLKICEKFGPNLDTubiquitination[1]
1415EAGTLTKKWHMAYHGubiquitination[3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. 
Sequence Annotation
 DOMAIN 41 207 NHR 1.
 DOMAIN 317 484 NHR 2.
 DOMAIN 520 686 NHR 3.
 DOMAIN 716 884 NHR 4.
 DOMAIN 913 1086 NHR 5.
 DOMAIN 1131 1294 NHR 6.
 MOD_RES 907 907 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1562 AA 
Protein Sequence
MAAGSGGSGG SGGGPGPGPG GGGGPSGSGS GPGSNGGLGS GGELHPRTGR LVSLSACGRT 60
ARRQQPGQEF NHGLVLSREP LRDGRVFTVR IDRKVNSWSG SIEIGVTALD PSVLDFPSSA 120
TGLKGGSWVV SGCSVLRDGR SVLEEYGQDL DQLGEGDRVG VERTVAGELR LWVNGRDCGV 180
AATGLPPRVW AVVDLYGKCT QITVLPPEPG FSPPTPIPTP PLEPLAPTED SALAEQGTSA 240
DEAFMVSPAQ ARPETFPNSL ESHNDFANME LSEVVSNTIL SAYNGGLLNV NLSSPPAGEG 300
LGSSGAATSP ILTSNDALLF HEKCGTLIKL SNNNKTAERR RPLDEFNNGV VMTNRPLRDN 360
EMFEIRIDKL VDKWSGSIEI GVTTHNPNSL EYPATMTNLQ SGTIMMSGCG ILTNGKGTRR 420
EYCEFSLDEL QEGDHIGLTR KSNSALHFFI NGIDQGVATP LTPPVVYGVV DLYGMAVKVT 480
IVHNNNHSDR LRRNNAILRA LSPEGALRRA APAAQAEPER LLFHPNCGQK AAITHEGRTA 540
LRPHATDDFN HGVVLSSRAL RDGEVFQVRI DKMVDKWAGS IEIGVTTHNP AYLQLPSTMT 600
NLRSGTWMMT GNGVMHNGTT ILDEYGHNLD RLKAGDTVGV VRREDGTLHF FVNGMTQGPA 660
AWNVPPGVYA VVDLYGQAAQ ATIVDDVEVA PVPEPLPEGN NQVSPSSPSS GAGGSDLRFH 720
QLHGSNAVIT NGGRTALRHN CRSEFNDAIV ISNRALRDGE LFEIVIQKMV DRWSGSIEAG 780
VTAIRPEDLE FPNTMTDIDY DTWMLSGTAI MQDGNTMRNN YGCDLDALGT GARIGMMRTA 840
KGDLHYFING QDQGAACSGL PPGKEVYAVV DLYGQCVQVS ITNATGPMDN SLATSNTATE 900
KSFPLHSPVA GVAHRFHSTC GKNVTLEEDG TRAVRAAGYA HGLVFSTKEL RAEEVFEVKV 960
EELDEKWAGS LRLGLTTLAP GEMGPGAGGG GPGLPPSLPE LRTKTTWMVS SCEVRRDGQL 1020
QRMNYGRNLE RLGVGSRVGV RRGADDTMHI LVDGEDMGPA ATGIAKNVWA VLDLYGPVRG 1080
VSIVSSTRLE ESEGTQPPSP SSDTGSEGEE DDEGEEHGLG GQNEVGIIPT TLEFLENHGK 1140
NILLSNGNRT ATRVASYNQG IVVINQPLVP QLLVQVRIDF LNRQWTSSLV LGVITCAPER 1200
LNFPASACAL KRAAWLLRGR GVFHNGLKIC EKFGPNLDTC PEGTILGLRL DSSGGLHLHV 1260
NGVDQGVAVP DVPQPCHALV DLYGQCEQVT IVNPEPGAAS GKSAGTQGDM EKADMVDGIK 1320
ESVCWGPPPA ASPLKSCEYH ALCSRFQELL LLPEDYFMPP PKRSLCYCES CRKLRGDEAH 1380
RRRGEPPREY ALPFGWCRFN LRVNPRLEAG TLTKKWHMAY HGSNVAAVRR VLDRGELGAG 1440
TASILSCRPL KGEPGVGFEE PGENCAPPRE EQPPPVLLSP SLQYAGAETL ASKVQFRDPK 1500
SQRTHQAQVA FQVCVRPGSY TPGPPSAALG EPPDPHFSPA ELEWVTKEKG ATLLCALLVR 1560
VE 1562 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR006573; Neu_Z. 
Pfam
 PF07177; Neuralized 
SMART
 SM00588; NEUZ 
PROSITE
 PS51065; NHR 
PRINTS