UniProt Accession

 CKLF_HUMAN; Q9UBR5; C9JE38; Q9UHM7; Q9UHN8; Q9UI41 

Genbank Protein ID

 AF135380; AF135381; AF145216; AF096895; AF057306; AF151058; AY358999; AY665769; AC010542; BC004380 

Genbank Nucleotide ID

 AAF19599.1; AAF19600.1; AAF19350.1; AAF06722.1; AAF21255.1; AAF36144.1; AAQ89358.1; AAT70694.1; AAH04380.1 

Protein Name

 Chemokine-like factor 

Protein Synonyms/Alias

 C32 

Gene Name

 CKLF 

Gene Synonyms/Alias

 CKLF1; HSPC224; UNQ410/PRO772 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MDNVQPKIKHRPFC	ubiquitination	[1, 2]
9	DNVQPKIKHRPFCFS	ubiquitination	[2]
131	DGALIYRKLLFNPSG	ubiquitination	[2, 3, 4]
142	NPSGPYQKKPVHEKK	ubiquitination	[2]
143	PSGPYQKKPVHEKKE	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. 

Sequence Annotation

 DOMAIN 13 133 MARVEL.  

Keyword

 Alternative splicing; Chemotaxis; Complete proteome; Cytokine; Membrane; Reference proteome; Secreted; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0008009; F:chemokine activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; IDA:UniProtKB.
 GO:0048247; P:lymphocyte chemotaxis; IDA:UniProtKB.
 GO:0048246; P:macrophage chemotaxis; IDA:UniProtKB.
 GO:0030593; P:neutrophil chemotaxis; IDA:UniProtKB.
 GO:0032940; P:secretion by cell; IDA:UniProtKB. 

Interpro

 IPR008253; Marvel. 

Pfam

  

SMART

  

PROSITE

 PS51225; MARVEL 

PRINTS