CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031511
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Armadillo repeat-containing protein 6 
Protein Synonyms/Alias
 cDNA FLJ50945, highly similar to Armadillo repeat-containing protein 6 
Gene Name
 ARMC6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29TRFCDQCKQDKACRFubiquitination[1]
32CDQCKQDKACRFLAAubiquitination[1]
41CRFLAAQKGAYPIIFubiquitination[1, 2, 3, 4, 5]
115CVRHACLKHEQNRQDubiquitination[1, 6]
125QNRQDLVKAGVLPLLubiquitination[1, 3]
174GHAHNHAKMIVQENKubiquitination[1]
181KMIVQENKGLKVLIEubiquitination[1, 4, 6]
184VQENKGLKVLIEATKubiquitination[1]
191KVLIEATKAFLDNPGubiquitination[1]
252SGVQELVKQVLSTLRubiquitination[1, 6, 7]
268IAGNDDVKDAIVRAGubiquitination[1, 3, 4, 5, 6, 7]
329VAALQAMKAHPQKAGubiquitination[1, 2, 3, 5, 6, 7]
339PQKAGVQKQACMLIRubiquitination[1, 3, 4]
357AHGQAFSKPILDLGAubiquitination[1, 3, 6]
383RDCEDVAKAALRDLGubiquitination[1, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MLSDLQESVA SSRPQEVSAY LTRFCDQCKQ DKACRFLAAQ KGAYPIIFTA WKLATAGDQG 60
LLLQSLNALS VLTDGQPDLL DAQGLQLLVA TLTQNADEAD LTCSGIRCVR HACLKHEQNR 120
QDLVKAGVLP LLTGAITHHG HHTDVVREAC WALRVMTFDD DIRVPFGHAH NHAKMIVQEN 180
KGLKVLIEAT KAFLDNPGIL SELCGTLSRL AIRNEFCQEV VDLGGLSILV SLLADCNDHQ 240
MRDQSGVQEL VKQVLSTLRA IAGNDDVKDA IVRAGGTESI VAAMTQHLTS PQVCEQSCAA 300
LCFLALRKPD NSRIIVEGGG AVAALQAMKA HPQKAGVQKQ ACMLIRNLVA HGQAFSKPIL 360
DLGAEALIMQ ARSAHRDCED VAKAALRDLG CHVELRELWT GQRGNLAP 408 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF00514; Arm 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS