UniProt Accession

 CKS2_HUMAN; P33552; Q6FGI9 

Genbank Protein ID

 X54942; AF506708; BT006630; CR542118; AL160054; CH471089; BC006458 

Genbank Nucleotide ID

 CAA38703.1; AAM22232.1; AAP35276.1; CAG46915.1; CAI41365.1; EAW62762.1; AAH06458.1 

Protein Name

 Cyclin-dependent kinases regulatory subunit 2 

Protein Synonyms/Alias

 CKS-2 

Gene Name

 CKS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MAHKQIYYSDK	acetylation	[1, 2, 3, 4]
4	****MAHKQIYYSDK	ubiquitination	[4, 5, 6, 7]
11	KQIYYSDKYFDEHYE	ubiquitination	[4, 7, 8]
30	MLPRELSKQVPKTHL	ubiquitination	[4, 5, 7]
34	ELSKQVPKTHLMSEE	ubiquitination	[7]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 4 4 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Cell cycle; Cell division; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 79 AA 

Protein Sequence

Gene Ontology

 GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007127; P:meiosis I; IEA:Compara.
 GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:UniProtKB.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
 GO:0007051; P:spindle organization; NAS:UniProtKB. 

Interpro

 IPR000789; Cyclin-dep_kinase_reg-sub. 

Pfam

 PF01111; CKS 

SMART

 SM01084; CKS 

PROSITE

 PS00944; CKS_1
 PS00945; CKS_2 

PRINTS

 PR00296; CYCLINKINASE.