| Tag | Content |
|---|
| CPLM ID | CPLM-024429 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tubulin polyglutamylase TTLL6 |
Protein Synonyms/Alias | Tubulin--tyrosine ligase-like protein 6 |
Gene Name | Ttll6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 498 | QEKKVFLKKARKEET | acetylation | [1] | | 499 | EKKVFLKKARKEETQ | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. |
Sequence Annotation | DOMAIN 57 400 TTL. |
Keyword | Alternative splicing; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Ligase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 822 AA |
Protein Sequence | MLQCLTSESE EGAEEREESS TEDLEELKEF VTLAFVRENT QKRLQNAQQH GKKKRKKKRL 60
VINLSNCRYD SVRRAAQQYG LREAGDNDDW TLYWTDYSVS LERVMEMKSY QKINHFPGMS 120
EICRKDLLAR NMSRMLKLFP KDFHFFPRTW CLPADWGDLQ TYSRTRKNKT YICKPDSGCQ 180
GRGIFITRSV KEIKPGEDMI CQLYISKPFI IDGFKFDLRV YVLVTSCDPL RVFVYNEGLA 240
RFATTSYSHP NLDNLDEICM HLTNYSINKH SSNFVQDAFS GSKRKLSTFN SYMKTHGYDV 300
EQIWRGIEDV IIKTLISAHP VIKHNYHTCF PSHTLNSACF EILGFDILLD RKLKPWLLEV 360
NHSPSFSTDS KLDKEVKDSL LYDALVLINL GNCDKKKVLE EERQRGRFLQ QCPNREIRLE 420
EVKGFQAMRL QKTEEYEKKN CGGFRLIYPG LNLEKYDKFF QDNSSLFQNT VASRARELYA 480
RQLIQELRQK QEKKVFLKKA RKEETQGESA GEQARDKVVR LQRQRQQPKC KTVATCPPKQ 540
SLHPVTLVSC TSGLLLNIRG LKKGEISESL EQKDTKEAML IPCKPVSARN YSSVPDLRSA 600
NPSCFEPEFH VPNAKVKEVK SAFMVNIEST AQPITSVESS RDATAPISTS LESLASMSLS 660
TSPECSSPES VHMVSYNHKQ QKASFHKPMQ EKKSKPLMFS KSRHLDLNCT SMKNDINRQY 720
LMSEILQKVQ MKKKRPLFPA PKSQYPTLSK ERCPHSRSSS RKKEMNSPSV FVLQASHSRA 780
ESLNDLLVVA TQARLDPRPS RSHSGTTTRD SSTQDPKHTA TA 822 |
Gene Ontology | GO:0036064; C:cilium basal body; ISS:UniProtKB. GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0015631; F:tubulin binding; IDA:UniProtKB. GO:0004835; F:tubulin-tyrosine ligase activity; IEA:InterPro. GO:0001578; P:microtubule bundle formation; IGI:MGI. GO:0051013; P:microtubule severing; IDA:MGI. GO:0018095; P:protein polyglutamylation; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |