UniProt Accession

 Q5SRN5_HUMAN; Q5SRN5 

Genbank Protein ID

 AL671277 

Genbank Nucleotide ID

  

Protein Name

 HLA class I histocompatibility antigen, A-68 alpha chain 

Protein Synonyms/Alias

  

Gene Name

 HLA-A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
92	DQETRNVKAQSQTDR	ubiquitination	[1]
145	RQDAYDGKDYIALNE	ubiquitination	[1]
168	DMAAQITKRKWEAAH	ubiquitination	[1, 2]
170	AAQITKRKWEAAHEA	ubiquitination	[1]
210	LQRTDPPKTHMTHHP	ubiquitination	[1]
346	GEGVKDRKGGSYTQA	ubiquitination	[1]
370	DVSLTACKV******	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Disulfide bond; Immunity; Membrane; MHC I; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; IEA:InterPro. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.