CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024076
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxysterols receptor LXR-alpha 
Protein Synonyms/Alias
 Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3 
Gene Name
 Nr1h3 
Gene Synonyms/Alias
 Lxra 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
432ALRLQDKKLPPLLSEacetylation[1]
Reference
 [1] SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
 Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L.
 Mol Cell. 2007 Oct 12;28(1):91-106. [PMID: 17936707] 
Functional Description
 Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. 
Sequence Annotation
 DNA_BIND 93 168 Nuclear receptor.
 ZN_FING 96 116 NR C4-type.
 ZN_FING 132 156 NR C4-type.
 REGION 213 432 Ligand-binding (Potential).  
Keyword
 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MSLWLEASMP DVSPDSATEL WKTEPQDAGD QGGNTCILRE EARMPQSTGV ALGIGLESAE 60
PTALLPRAET LPEPTELRPQ KRKKGPAPKM LGNELCSVCG DKASGFHYNV LSCEGCKGFF 120
RRSVIKGARY VCHSGGHCPM DTYMRRKCQE CRLRKCRQAG MREECVLSEE QIRLKKLKRQ 180
EEEQAQATSV SPRVSSPPQV LPQLSPEQLG MIEKLVAAQQ QCNRRSFSDR LRVTPWPIAP 240
DPQSREARQQ RFAHFTELAI VSVQEIVDFA KQLPGFLQLS REDQIALLKT SAIEVMLLET 300
SRRYNPGSES ITFLKDFSYN REDFAKAGLQ VEFINPIFEF SRAMNELQLN DAEFALLIAI 360
SIFSADRPNV QDQLQVERLQ HTYVEALHAY VSINHPHDPL MFPRMLMKLV SLRTLSSVHS 420
EQVFALRLQD KKLPPLLSEI WDVHE 445 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0032810; F:sterol response element binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043277; P:apoptotic cell clearance; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IGI:BHF-UCL.
 GO:0006633; P:fatty acid biosynthetic process; TAS:BHF-UCL.
 GO:0010887; P:negative regulation of cholesterol storage; IGI:BHF-UCL.
 GO:0050728; P:negative regulation of inflammatory response; IDA:BHF-UCL.
 GO:0032369; P:negative regulation of lipid transport; IEA:Compara.
 GO:0043031; P:negative regulation of macrophage activation; IDA:BHF-UCL.
 GO:0090188; P:negative regulation of pancreatic juice secretion; IMP:BHF-UCL.
 GO:0048550; P:negative regulation of pinocytosis; IEA:Compara.
 GO:0045861; P:negative regulation of proteolysis; IMP:BHF-UCL.
 GO:0090341; P:negative regulation of secretion of lysosomal enzymes; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0032270; P:positive regulation of cellular protein metabolic process; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.
 GO:2000189; P:positive regulation of cholesterol homeostasis; IEA:Compara.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010870; P:positive regulation of receptor biosynthetic process; IEA:Compara.
 GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL. 
Interpro
 IPR023257; Liver_X_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR02034; LIVERXRECPTR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.