UniProt Accession

 NUBP1_MOUSE; Q9R060; Q3U053; Q7TMI1; Q9CRM5 

Genbank Protein ID

 AF114170; AK020141; AK157212; BC055436 

Genbank Nucleotide ID

 AAF01786.1; BAB32007.1; BAE34002.1; AAH55436.1 

Protein Name

 Cytosolic Fe-S cluster assembly factor NUBP1 

Protein Synonyms/Alias

 Nucleotide-binding protein 1; NBP 1 

Gene Name

 Nubp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	KMKTVRHKLLVLSGK	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Implicated in the regulation of centrosome duplication. 

Sequence Annotation

 NP_BIND 62 69 ATP (Potential).
 METAL 8 8 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 22 22 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 25 25 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 31 31 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 235 235 Iron-sulfur 2 (4Fe-4S); shared with
 METAL 238 238 Iron-sulfur 2 (4Fe-4S); shared with
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 4Fe-4S; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 320 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0006879; P:cellular iron ion homeostasis; IEA:Compara.
 GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR025723; Anion-transp_ATPase-like_dom.
 IPR019591; ATPase-like_ParA/MinD.
 IPR000808; Mrp_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF02374; ArsA_ATPase
 PF10609; ParA 

SMART

 SM00382; AAA 

PROSITE

 PS01215; MRP 

PRINTS