UniProt Accession

 LSG1_HUMAN; Q9H089; A0JLT4; A0PJK3; A6NI18; Q7L9H8; Q9NUK8 

Genbank Protein ID

 AL136897; AC046143; BC015042; BC040119; BC068500; AK002163 

Genbank Nucleotide ID

 CAB66831.1; AAH15042.1; AAH40119.1; AAH68500.1; BAA92116.1 

Protein Name

 Large subunit GTPase 1 homolog 

Protein Synonyms/Alias

 hLsg1 

Gene Name

 LSG1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	VAEKLNIKFVPAEAR	ubiquitination	[1]
151	VRLEEEQKLILTPFE	ubiquitination	[2]
213	ENVILINKADLLTAE	ubiquitination	[3]
383	LHTGRKVKDGQLTVG	ubiquitination	[2]
411	NTIMGNKKVSVSATP	ubiquitination	[2]
569	HQRLLENKMNSDEIK	ubiquitination	[2, 3]
576	KMNSDEIKMQLGRNK	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). 

Sequence Annotation

 DOMAIN 398 449 G.
 NP_BIND 212 215 GTP (Potential).
 NP_BIND 393 400 GTP (Potential).
 NP_BIND 437 440 GTP (Potential).
 MOD_RES 252 252 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Endoplasmic reticulum; GTP-binding; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 658 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IDA:UniProtKB.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0051168; P:nuclear export; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042254; P:ribosome biogenesis; IBA:RefGenome. 

Interpro

 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01926; MMR_HSR1 

SMART

  

PROSITE

  

PRINTS

 PR00326; GTP1OBG.