CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016771
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-CoA acetyltransferase, cytosolic 
Protein Synonyms/Alias
 Cytosolic acetoacetyl-CoA thiolase 
Gene Name
 Acat2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
233SNLEAMGKLKPYFLTubiquitination[1]
235LEAMGKLKPYFLTDGubiquitination[1]
265AAAVVLMKKTEAERRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 92 92 Acyl-thioester intermediate (By
 ACT_SITE 353 353 Proton acceptor (By similarity).
 ACT_SITE 383 383 Proton acceptor (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 200 200 N6-acetyllysine (By similarity).
 MOD_RES 233 233 N6-acetyllysine (By similarity).
 MOD_RES 235 235 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Acyltransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 397 AA 
Protein Sequence
MNAGSDPVVI VSAARTAIGS FNGALSTVPV HEMGTTVIKE VLQRAKVAPE EVSEVIFGHV 60
LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAAQSIAMGD STIVVAGGME 120
NMSKAPHLTH LRTGVRMGEV PLADSILCDG LTDAFHNYHM GITAENVAKK WQVSREAQDK 180
VAVLSQNRAE HAQKAGHFDK EIVPVLVSSR KGLTEVKIDE FPRHGSNLEA MGKLKPYFLT 240
DGTGTVTPAN ASGMNDGAAA VVLMKKTEAE RRMLKPLARI VSWSQAGVEP SVMGVGPIPA 300
IKQAVAKAGW SLEDVDLFEI NEAFAAVSAA IAKELGLNPE KVNIDGGAIA LGHPLGASGC 360
RILVTLLHTL ERVGGTRGVA ALCIGGGMGV AMCVQRG 397 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:EC. 
Interpro
 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020610; Thiolase_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 
Pfam
 PF02803; Thiolase_C
 PF00108; Thiolase_N 
SMART
  
PROSITE
 PS00098; THIOLASE_1
 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 
PRINTS