UniProt Accession

 PNKD_HUMAN; Q8N490; A8K1F2; Q96A48; Q9BU26; Q9NSX4; Q9ULN6; Q9Y4T1 

Genbank Protein ID

 AF417001; AY039043; AF318057; AF390031; AY358753; AK289867; AL080092; AL137675; CH471063; CH471063; BC002937; BC021118; BC036457; AB033010 

Genbank Nucleotide ID

 AAL08573.1; AAK83449.1; AAL25716.1; AAM73649.1; AAQ89113.1; BAF82556.1; CAB45707.2; CAB70870.2; EAW70602.1; EAW70604.1; AAH02937.1; AAH21118.1; AAH36457.1; BAA86498.1 

Protein Name

 Probable hydrolase PNKD 

Protein Synonyms/Alias

 Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2 

Gene Name

 PNKD 

Gene Synonyms/Alias

 KIAA1184; MR1; TAHCCP2; FKSG19; UNQ2491/PRO5778 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	VVAATALKGRGARNA	ubiquitination	[1]
244	LLDGEPYKGPSCLFS	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity). 

Sequence Annotation

 REGION 291 293 Substrate (By similarity).
 REGION 376 379 Substrate (By similarity).
 METAL 172 172 Zinc 1 (By similarity).
 METAL 174 174 Zinc 1 (By similarity).
 METAL 176 176 Zinc 2 (By similarity).
 METAL 177 177 Zinc 2 (By similarity).
 METAL 229 229 Zinc 1 (By similarity).
 METAL 253 253 Zinc 1 (By similarity).
 METAL 253 253 Zinc 2 (By similarity).
 METAL 291 291 Zinc 2 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Dystonia; Hydrolase; Membrane; Metal-binding; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 385 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006750; P:glutathione biosynthetic process; IEA:InterPro. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS