UniProt Accession

 IMPA1_MOUSE; O55023 

Genbank Protein ID

 AF042730 

Genbank Nucleotide ID

 AAB97469.1 

Protein Name

 Inositol monophosphatase 1 

Protein Synonyms/Alias

 IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1 

Gene Name

 Impa1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	LMSSIKEKYPCHSFI	acetylation	[1]
156	SQQEDITKSLLVTEL	ubiquitination	[2]
181	IVLSNMEKLCSIPIH	acetylation	[1]
260	ANSITLAKRIAKEIE	acetylation	[1]
260	ANSITLAKRIAKEIE	ubiquitination	[2]
264	TLAKRIAKEIEIIPL	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). 

Sequence Annotation

 REGION 92 95 Substrate binding (By similarity).
 REGION 194 196 Substrate binding (By similarity).
 METAL 70 70 Magnesium 1 (By similarity).
 METAL 90 90 Magnesium 1 (By similarity).
 METAL 90 90 Magnesium 2 (By similarity).
 METAL 92 92 Magnesium 1; via carbonyl oxygen (By
 METAL 93 93 Magnesium 2 (By similarity).
 METAL 220 220 Magnesium 2 (By similarity).
 BINDING 70 70 Substrate (By similarity).
 BINDING 213 213 Substrate (By similarity).
 BINDING 220 220 Substrate (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Lithium; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISO:MGI.
 GO:0008934; F:inositol monophosphate 1-phosphatase activity; ISO:MGI.
 GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:EC.
 GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; ISO:MGI.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006020; P:inositol metabolic process; TAS:MGI.
 GO:0046855; P:inositol phosphate dephosphorylation; ISO:MGI.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. 

Interpro

 IPR020583; Inositol_monoP_metal-BS.
 IPR020552; Inositol_monoPase_Li-sen.
 IPR000760; Inositol_monophosphatase.
 IPR020550; Inositol_monophosphatase_CS. 

Pfam

 PF00459; Inositol_P 

SMART

  

PROSITE

 PS00629; IMP_1
 PS00630; IMP_2 

PRINTS

 PR00377; IMPHPHTASES.
 PR00378; LIIMPHPHTASE.