UniProt Accession

 CD1C_HUMAN; P29017; Q5TDJ7; Q6IAS4; Q9UMM0; Q9UN96 

Genbank Protein ID

 M22178; M22174; M22175; M22176; M22177; M28827; CR457080; AL121986; BC126465; BC126467; AF142667; M14667 

Genbank Nucleotide ID

 AAA51942.1; AAA51942.1; AAA51942.1; AAA51942.1; AAA51942.1; AAA51941.1; CAG33361.1; CAI10850.1; AAI26466.1; AAI26468.1; AAD37580.1; AAA51938.1 

Protein Name

 T-cell surface glycoprotein CD1c 

Protein Synonyms/Alias

 CD1c 

Gene Name

 CD1C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	HASQDYSKYPFEVQV	ubiquitination	[1]
197	LGLLDAGKMYVHRQV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. 

Sequence Annotation

 DOMAIN 206 296 Ig-like.
 MOTIF 329 332 Internalization signal.
 CARBOHYD 38 38 N-linked (GlcNAc...).
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 75 75 N-linked (GlcNAc...).
 CARBOHYD 78 78 N-linked (GlcNAc...); atypical.
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 DISULFID 120 185
 DISULFID 225 280 By similarity.  

Keyword

 3D-structure; Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Immunity; Immunoglobulin domain; Lipid-binding; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030883; F:endogenous lipid antigen binding; IDA:UniProtKB.
 GO:0030884; F:exogenous lipid antigen binding; IDA:UniProtKB.
 GO:0051861; F:glycolipid binding; IDA:UniProtKB.
 GO:0071723; F:lipopeptide binding; IDA:UniProtKB.
 GO:0019882; P:antigen processing and presentation; IEA:InterPro.
 GO:0002286; P:T cell activation involved in immune response; IDA:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE 

PRINTS