| Tag | Content |
|---|
| CPLM ID | CPLM-027092 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | S-methyl-5'-thioadenosine phosphorylase |
Protein Synonyms/Alias | 5'-methylthioadenosine phosphorylase |
Gene Name | Mtap |
Gene Synonyms/Alias | Mtap_predicted |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 77 | YVDTPFGKPSDALIL | acetylation | [1] | | 240 | EVLIEMAKKLGLRCH | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity). |
Sequence Annotation | REGION 303 305 Substrate binding (By similarity).
BINDING 55 55 Phosphate (By similarity).
BINDING 279 279 Substrate; via amide nitrogen (By
BINDING 280 280 Phosphate (By similarity). |
Keyword | Complete proteome; Cytoplasm; Glycosyltransferase; Nucleus; Purine salvage; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 391 AA |
Protein Sequence | MEVGGRCWLI LLALGLIAPQ SPLGPALRPA VDFPGADMAS GSACTAVKIG IIGGTGLDDP 60
EILEGRTEKY VDTPFGKPSD ALILGKIKNV DCVLLASMYV LDRMCEFLLL PFCVQLNSLH 120
EIPPGSSCHT SYLFAFVARW ERRVRWLARV LCERAFVPSS ASTSVQWKET KHSKEITQRS 180
KASRFSTTVQ QQAIREECQT SLRPQTFYDG SHCSARGVCH IPMAEPFCPK TREVLIEMAK 240
KLGLRCHSKG TIVTIEGPRF SSRAESFIFR TWGADVINMT TVPEVVLAKE AGLCYASIAM 300
ATDYDCWKEH EEAVSVDGVL KTMKENANKA KSLLLTTIPQ IGSMEWSETL RNLKVVAVKL 360
YGEKKRELHQ KSSGGMLQML ASSKDSGQLA E 391 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004645; F:phosphorylase activity; IEA:InterPro. GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IDA:RGD. GO:0019509; P:L-methionine salvage from methylthioadenosine; IMP:RGD. GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. GO:0033574; P:response to testosterone stimulus; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |