CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029067
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Filamin A 
Protein Synonyms/Alias
  
Gene Name
 FLNA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
6**MPATEKDLAEDAPubiquitination[1]
16AEDAPWKKIQQNTFTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2315 AA 
Protein Sequence
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVSKRIANL QTDLSDGLRL IALLEVLSQK 60
KMHRKHNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK AIVDGNLKLI LGLIWTLILH 120
YSISMPMWDE EEDEEAKKQT PKQRLLGWIQ NKLPQLPITN FSRDWQSGRA LGALVDSCAP 180
GLCPDWDSWD ASKPVTNARE AMQQADDWLG IPQVITPEEI VDPNVDEHSV MTYLSQFPKA 240
KLKPGAPLRP KLNPKKARAY GPGIEPTGNM VKKRAEFTVE TRSAGQGEVL VYVEDPAGHQ 300
EEAKVTANND KNRTFSVWYV PEVTGTHKVT VLFAGQHIAK SPFEVYVDKS QGDASKVTAQ 360
GPGLEPSGNI ANKTTYFEIF TAGAGTGEVE VVIQDPMGQK GTVEPQLEAR GDSTYRCSYQ 420
PTMEGVHTVH VTFAGVPIPR SPYTVTVGQA CNPSACRAVG RGLQPKGVRV KETADFKVYT 480
KGAGSGELKV TVKGPKGEER VKQKDLGDGV YGFEYYPMVP GTYIVTITWG GQNIGRSPFE 540
VKVGTECGNQ KVRAWGPGLE GGVVGKSADF VVEAIGDDVG TLGFSVEGPS QAKIECDDKG 600
DGSCDVRYWP QEAGEYAVHV LCNSEDIRLS PFMADIRDAP QDFHPDRVKA RGPGLEKTGV 660
AVNKPAEFTV DAKHGGKAPL RVQVQDNEGC PVEALVKDNG NGTYSCSYVP RKPVKHTAMV 720
SWGGVSIPNS PFRVNVGAGS HPNKVKVYGP GVAKTGLKAH EPTYFTVDCA EAGQGDVSIG 780
IKCAPGVVGP AEADIDFDII RNDNDTFTVK YTPRGAGSYT IMVLFADQAT PTSPIRVKVE 840
PSHDASKVKA EGPGLSRTGV ELGKPTHFTV NAKAAGKGKL DVQFSGLTKG DAVRDVDIID 900
HHDNTYTVKY TPVQQGPVGV NVTYGGDPIP KSPFSVAVSP SLDLSKIKVS GLGEKVDVGK 960
DQEFTVKSKG AGGQGKVASK IVGPSGAAVP CKVEPGLGAD NSVVRFLPRE EGPYEVEVTY 1020
DGVPVPGSPF PLEAVAPTKP SKVKAFGPGL QGGSAGSPAR FTIDTKGAGT GGLGLTVEGP 1080
CEAQLECLDN GDGTCSVSYV PTEPGDYNIN ILFADTHIPG SPFKAHVVPC FDASKVKCSG 1140
PGLERATAGE VGQFQVDCSS AGSAELTIEI CSEAGLPAEV YIQDHGDGTH TITYIPLCPG 1200
AYTVTIKYGG QPVPNFPSKL QVEPAVDTSG VQCYGPGIEG QGVFREATTE FSVDARALTQ 1260
TGGPHVKARV ANPSGNLTET YVQDRGDGMY KVEYTPYEEG LHSVDVTYDG SPVPSSPFQV 1320
PVTEGCDPSR VRVHGPGIQS GTTNKPNKFT VETRGAGTGG LGLAVEGPSE AKMSCMDNKD 1380
GSCSVEYIPY EAGTYSLNVT YGGHQVPGSP FKVPVHDVTD ASKVKCSGPG LSPGMVRANL 1440
PQSFQVDTSK AGVAPLQVKV QGPKGLVEPV DVVDNADGTQ TVNYVPSREG PYSISVLYGD 1500
EEVPRSPFKV KVLPTHDASK VKASGPGLNT TGVPASLPVE FTIDAKDAGE GLLAVQITDP 1560
EGKPKKTHIQ DNHDGTYTVA YVPDVTGRYT ILIKYGGDEI PFSPYRVRAV PTGDASKCTV 1620
TVSIGGHGLG AGIGPTIQIG EETVITVDTK AAGKGKVTCT VCTPDGSEVD VDVVENEDGT 1680
FDIFYTAPQP GKYVICVRFG GEHVPNSPFQ VTALAGDQPS VQPPLRSQQL APQYTYAQGG 1740
QQTWAPERPL VGVNGLDVTS LRPFDLVIPF TIKKGEITGE VRMPSGKVAQ PTITDNKDGT 1800
VTVRYAPSEA GLHEMDIRYD NMHIPGSPLQ FYVDYVNCGH VTAYGPGLTH GVVNKPATFT 1860
VNTKDAGEGG LSLAIEGPSK AEISCTDNQD GTCSVSYLPV LPGDYSILVK YNEQHVPGSP 1920
FTARVTGDDS MRMSHLKVGS AADIPINISE ISFEDRKDGS CGVAYVVQEP GDYEVSVKFN 1980
EEHIPDSPFV VPVASPSGDA RRLTVSSLQE SGLKVNQPAS FAVSLNGAKG AIDAKVHSPS 2040
GALEECYVTE IDQDKYAVRF IPRENGVYLI DVKFNGTHIP GSPFKIRVGE PGHGGDPGLV 2100
SAYGAGLEGG VTGNPAEFVV NTSNAGAGAL SVTIDGPSKV KMDCQECPEG YRVTYTPMAP 2160
GSYLISIKYG GPYHIGGSPF KAKVTGPRLV SNHSLHETSS VFVDSLTKAT CAPQHGAPGP 2220
GPADASKVVA KGLGLSKAYV GQKSSFTVDC SKAGNNMLLV GVHGPRTPCE EILVKHVGSR 2280
LYSVSYLLKD KGEYTLVVKW GDEHIPGSPY RVVVP 2315 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001298; Filamin.
 IPR017868; Filamin/ABP280_repeat-like.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set. 
Pfam
 PF00307; CH
 PF00630; Filamin 
SMART
 SM00033; CH
 SM00557; IG_FLMN 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS50194; FILAMIN_REPEAT 
PRINTS