CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032404
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integral membrane protein 2C 
Protein Synonyms/Alias
  
Gene Name
 ITM2C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
125WELLMNVKRGTYLPQubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 205 AA 
Protein Sequence
MGMVVLLMGL VFASVYIYRY FFLAQLARDN FFRCGVLYED SLSSQVRTQM ELEEDVKIYL 60
DENYERINVP VPQFGGGDPA DIIHDFQRGL TAYHDISLDK CYVIELNTTI VLPPRNFWEL 120
LMNVKRGTYL PQTYIIQEEM VVTEHVSDKE ALGSFIYHLC NGKDTYRLRR RATRRRINKR 180
GAKNCNAIRH FENTFVVETL ICGVV 205 
Gene Ontology
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0012502; P:induction of programmed cell death; IEA:Compara. 
Interpro
 IPR007084; BRICHOS_dom. 
Pfam
 PF04089; BRICHOS 
SMART
 SM01039; BRICHOS 
PROSITE
 PS50869; BRICHOS 
PRINTS