CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038337
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Homeodomain-interacting protein kinase 1 
Protein Synonyms/Alias
  
Gene Name
 Hipk1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
421YLLSAGTKTTRFFNRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1176 AA 
Protein Sequence
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQASSSH 60
QVANFNLPAY DQGLLLPAPA VEHIVVTAAD SSGSAATATF QSSQTLTHRS NVSLLEPYQK 120
CGLKRKSEEV ESNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM SHLLDFPHSS HVKSCFQNME 540
ICKRRVHMYD TASVLASSST AAAATLSLAN SDVSLLNYQS ALYPSSAAPV PGVAQQGVSL 600
QPGTTQICTQ TDPFQQTFIV CPPAFQTGLQ ATTKHSGFPV RMDNAVPIVP QAPAAQPLQI 660
QSGVLTQGSC TPLMVATLHP QVATITPQYA VPFTLSCAAG RPALVEQTAA VLQAWPGGTQ 720
QILLPSAWQQ LPGVALHNSV QPAAVIPEAM GSSQQLADWR NAHSHGNQYS TIMQQPSLLT 780
NHVTLATAQP LNVGVAHVVR QQQSSSLPSK KNKQSAPVSS KSSLEVLPSQ VYSLVGSSPL 840
RTTSSYNSLV PVQDQHQPII IPDTPSPPVS VITIRSDTDE EEDNKYKPNS SSLKARSNVI 900
SYVTVNDSPD SDSSLSSPHP TDTLSALRGN SGTLLEGPGR PAADGIGTRT IIVPPLKTQL 960
GDCTVATQAS GLLSSKTKPV ASVSGQSSGC CITPTGYRAQ RGGASAVQPL NLSQNQQSSS 1020
ASTSQERSSN PAPRRQQAFV APLSQAPYAF QHGSPLHSTG HPHLAPAPAH LPSQPHLYTY 1080
AAPTSAAALG STSSIAHLFS PQGSSRHAAA YTTHPSTLVH QVPVSVGPSL LTSASVAPAQ 1140
YQHQFATQSY IGSSRGSTIY TGYPLSPTKI SQYSYL 1176 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016607; C:nuclear speck; IDA:MGI.
 GO:0016605; C:PML body; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IGI:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0007224; P:smoothened signaling pathway; IGI:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS