CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger CCCH domain-containing protein 15 
Protein Synonyms/Alias
 DRG family-regulatory protein 1; Epo-immediate response gene protein FM22 
Gene Name
 Zc3h15 
Gene Synonyms/Alias
 Dfrp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
27KEKIIEDKTFGLKNKacetylation[1]
27KEKIIEDKTFGLKNKubiquitination[2]
44AKQQKFIKAVTHQVKubiquitination[2]
86QELNELFKPVVAAQKubiquitination[2]
93KPVVAAQKISKGADPubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Protects DRG1 from proteolytic degradation. 
Sequence Annotation
 ZN_FING 99 126 C3H1-type 1.
 ZN_FING 174 212 C3H1-type 2.
 REGION 236 260 Required for interaction with DRG1.
 MOD_RES 351 351 Phosphoserine (By similarity).
 MOD_RES 381 381 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 426 AA 
Protein Sequence
MPPKKQAQAG GSKKAEQKKK EKIIEDKTFG LKNKKGAKQQ KFIKAVTHQV KFGQQNPRQV 60
AQSEAEKKLK KDDKKKELQE LNELFKPVVA AQKISKGADP KSVVCAFFKQ GQCTKGDKCK 120
FSHDLTLERK CEKRSVYIDA RDEELEKDTM DNWDEKKLEE VVNKKHGEAE KKKPKTQIVC 180
RHFLEAIENN KYGWFWVCPG GGDNCMYRHA LPPGFVLKKD KKKEEKEDEI SLEDLIERER 240
SALGPNVTKI TLESFLAWKK RKRQEKIDKL EQDMERRKAD FKAGKALVIS GREVFEFRPE 300
LVNDDDEEAD DTRYIQGTGG DEVDDSMGVN DIDISLYVPR DVEETGITVA SVERFSTYAP 360
DKDENKLSEA SGGLAENGER SDLDEDSGGG GQENGSIDAV PVDENLFTGE DLDELEEELN 420
TLDLEE 426 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI. 
Interpro
 IPR000571; Znf_CCCH. 
Pfam
 PF00642; zf-CCCH 
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1 
PRINTS