UniProt Accession

 ANXA2_RAT; Q07936 

Genbank Protein ID

 X66871; L13039; S73559; S73557; BC059136 

Genbank Nucleotide ID

 CAA47343.1; AAA40741.1; AAB31934.2; AAB31933.2; AAH59136.1 

Protein Name

 Annexin A2 

Protein Synonyms/Alias

 Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36 

Gene Name

 Anxa2 

Gene Synonyms/Alias

 Anx2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
28	PSAYGSVKPYTNFDA	acetylation	[1]
49	IETAIKTKGVDEVTI	acetylation	[1]
104	TVMLGLLKTPAQYDA	acetylation	[1]
115	QYDASELKASMKGLG	acetylation	[1]
119	SELKASMKGLGTDED	acetylation	[1]
148	QEINRVYKEMYKTDL	acetylation	[1]
152	RVYKEMYKTDLEKDI	acetylation	[1]
157	MYKTDLEKDIISDTS	acetylation	[1]
212	RKGTDVPKWISIMTE	acetylation	[1]
227	RSVCHLQKVFERYKS	acetylation	[1]
279	DRLYDSMKGKGTRDK	acetylation	[1]
286	KGKGTRDKVLIRIMV	acetylation	[1]
302	RSEVDMLKIRSEFKR	acetylation	[1]
308	LKIRSEFKRKYGKSL	acetylation	[1]
313	EFKRKYGKSLYYFIQ	acetylation	[1]
324	YFIQQDTKGDYQKAL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. 

Sequence Annotation

 REPEAT 42 102 Annexin 1.
 REPEAT 114 174 Annexin 2.
 REPEAT 199 259 Annexin 3.
 REPEAT 274 334 Annexin 4.
 REGION 2 24 S100A10-binding site (Potential).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 24 24 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 26 26 Phosphoserine; by PKC (By similarity).  

Keyword

 Acetylation; Alternative splicing; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Extracellular matrix; Phosphoprotein; Reference proteome; Repeat; Secreted; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
 GO:0005938; C:cell cortex; IDA:RGD.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0044354; C:macropinosome; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0035749; C:myelin sheath adaxonal region; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0001726; C:ruffle; IDA:RGD.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0031982; C:vesicle; IDA:RGD.
 GO:0051015; F:actin filament binding; TAS:RGD.
 GO:0005509; F:calcium ion binding; TAS:RGD.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:RGD.
 GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007589; P:body fluid secretion; IMP:RGD.
 GO:0071229; P:cellular response to acid; IEA:Compara.
 GO:0030199; P:collagen fibril organization; IEA:Compara.
 GO:0042730; P:fibrinolysis; IEA:Compara.
 GO:0051099; P:positive regulation of binding; IEA:Compara.
 GO:0048146; P:positive regulation of fibroblast proliferation; IMP:RGD.
 GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
 GO:0031340; P:positive regulation of vesicle fusion; IEA:Compara.
 GO:0072661; P:protein targeting to plasma membrane; IMP:RGD.
 GO:0051917; P:regulation of fibrinolysis; TAS:RGD. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002389; AnnexinII. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00198; ANNEXINII.