CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021032
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankycorbin 
Protein Synonyms/Alias
 Ankyrin repeat and coiled-coil structure-containing protein; Novel retinal pigment epithelial cell protein; Retinoic acid-induced protein 14; p125 
Gene Name
 Rai14 
Gene Synonyms/Alias
 Kiaa1334; Norpeg 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
444DSLHDLQKRLESSEAubiquitination[1]
454ESSEAEKKQLQDELQubiquitination[1]
505KEVLSVQKQMKLGLLubiquitination[1]
508LSVQKQMKLGLLSQEubiquitination[1]
935QNQLAECKKHHQEVIacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
 REPEAT 18 51 ANK 1.
 REPEAT 52 81 ANK 2.
 REPEAT 85 114 ANK 3.
 REPEAT 118 147 ANK 4.
 REPEAT 151 180 ANK 5.
 REPEAT 184 213 ANK 6.
 REPEAT 217 247 ANK 7.
 MOTIF 270 276 Nuclear localization signal (By
 MOD_RES 249 249 Phosphothreonine (By similarity).
 MOD_RES 293 293 Phosphoserine (By similarity).
 MOD_RES 295 295 Phosphothreonine (By similarity).
 MOD_RES 297 297 Phosphothreonine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 340 340 Phosphoserine (By similarity).
 MOD_RES 341 341 Phosphoserine (By similarity).
 MOD_RES 358 358 Phosphoserine (By similarity).
 MOD_RES 513 513 Phosphoserine (By similarity).
 MOD_RES 516 516 Phosphoserine (By similarity).  
Keyword
 ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 979 AA 
Protein Sequence
MKSLKAKFRK SDTNEWNKND DRLLQAVENG DAEKVASLLG KKGASATKHD SEGKTAFHLA 60
AAKGHVECLK VMVTHGVDVT AQDSSGHSAL HVAAKNGHPE CIRKLLQYKS PAENIDNSGK 120
TALHYAAAQG CLQAVQLLCE HKSPINLKDL DGNIPLLVAV QNGHSEACHF LLDHGADVNS 180
RDKNGRTALM LACETGSSNT VDALIKKGAD LSLVDSLGHN ALHYSKLSEN AGIQNLLLSK 240
ISQDADLKTP TKPKQHDQVS KISSERSGTP KKRKAPPPPI SPTQLSDVSS PRSITSTPLS 300
GKESVFFAEA PFKAEISSIQ ENKDRLSDST AGADSLLDIS SEADQQDLLV LLQAKVASLT 360
LHNKELQDKL QAKSPKDKEA EADLSFQSFH STQTDLAPSP GKASDIPSSD AKSSPPVEHP 420
AGTSTTDNDV IIRQLQDSLH DLQKRLESSE AEKKQLQDEL QSQRTDTLCL NNTEISENGS 480
DLSQKLKETQ SKYEEAMKEV LSVQKQMKLG LLSQESADGY SHLREAPADE DIDTLKQDLQ 540
KAVEESARNK ERVRELETKL AEKEQAEATK PPAEACEELR SSYCSVIENM NKEKAFLFEK 600
YQQAQEEIMK LKDTLKSQMP QEAPDDSGDM KEAMNRMIDE LNKQVSELSQ LYREAQAELE 660
DYRKRKSLED AAEYIHKAEH ERLMHVSNLS RAKSEEALSE MKSQYSKVLN ELTQLKQLVD 720
AHKENSVSIT EHLQVITTLR TTAKEMEEKI SALTGHLANK EAEVAKLEKQ LAEEKAAVSD 780
AMVPKSSYEK LQASLESEVN ALATKLKESV REREKAHSEV AQVRSEVSQA RREKDNIQTL 840
LKAKEQEVTA LVQKFQRAQE ELAGMRRCSE TSSKLEEDKD EKINEMTREV LKLKEALNSL 900
SQLSYSTSSS KRQSQQLDLL QQQVKQLQNQ LAECKKHHQE VISVYRMHLL YAVQGQMDED 960
VQKVLKQILT MCKNQSQKK 979 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF00023; Ank
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR01415; ANKYRIN.