CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein DLX-3 
Protein Synonyms/Alias
  
Gene Name
 DLX3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112AQDPVSVKEEPEAEVsumoylation[1]
Reference
 [1] SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity.
 Duverger O, Chen SX, Lee D, Li T, Chock PB, Morasso MI.
 J Cell Biochem. 2011 Feb;112(2):445-52. [PMID: 21268066
Functional Description
 Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. 
Sequence Annotation
 DNA_BIND 129 188 Homeobox.  
Keyword
 Amelogenesis imperfecta; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 287 AA 
Protein Sequence
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESSVTDL GYYSAPQHDY YSGQPYGQTV 60
NPYTYHHQFN LNGLAGTGAY SPKSEYTYGA SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR 120
MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR 180
RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARSQ LPPPLPYSAS 240
PSYLDDPTNS WYHAQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY 287 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara. 
Interpro
 IPR022135; Distal-less_N.
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR000047; HTH_motif. 
Pfam
 PF12413; DLL_N
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00024; HOMEOBOX.
 PR00031; HTHREPRESSR.