CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030631
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 General transcription factor IIH subunit 1 
Protein Synonyms/Alias
 General transcription factor IIH, polypeptide 1, 62kDa, isoform CRA_b; cDNA FLJ45269 fis, clone BRHIP2029529, highly similar to TFIIH basal transcription factor complex p62 subunit 
Gene Name
 GTF2H1 
Gene Synonyms/Alias
 hCG_1992280 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102VPHNMTEKEFWTRFFubiquitination[1]
124DRLNTGSKDLFAECAacetylation[2, 3]
124DRLNTGSKDLFAECAubiquitination[4]
254LGKNNSVKTIALNLKubiquitination[4]
261KTIALNLKKSDRYYHubiquitination[4]
388LERFQVTKLCPFQEKubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 432 AA 
Protein Sequence
MLQEDPVLFQ LYKDLVVSQV ISAEEFWANR LNVNATDSSS TSNHKQDVGI SAAFLADVRP 60
QTDGCNGLRY NLTSDIIESI FRTYPAVKMK YAENVPHNMT EKEFWTRFFQ SHYFHRDRLN 120
TGSKDLFAEC AKIDEKGLKT MVSLGVKNPL LDLTALEDKP LDEGYGISSV PSASNSKSIK 180
ENSNAAIIKR FNHHSAMVLA AGLRKQEAQN EQTSEPSNMD GNSGDADCFQ PAVKRAKLQE 240
SIEYEDLGKN NSVKTIALNL KKSDRYYHGP TPIQSLQYAT SQDIINSFQS IRQEMEAYTP 300
KLTQVLSSSA ASSTITALSP GGALMQGGTQ QAINQMVPND IQSELKHLYV AVGELLRHFW 360
SCFPVNTPFL EEKVVKMKSN LERFQVTKLC PFQEKIRRQY LSTNLVSHIE EMLQTAYNKL 420
HTWQSRRLMK KT 432 
Gene Ontology
 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR005607; BSD.
 IPR027079; Tfb1/p62. 
Pfam
 PF03909; BSD 
SMART
 SM00751; BSD 
PROSITE
 PS50858; BSD 
PRINTS