CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium-activated potassium channel subunit alpha-1 
Protein Synonyms/Alias
  
Gene Name
 Kcnma1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
458FSMRSFIKIEEDTWQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1053 AA 
Protein Sequence
QEAQKINNGS SQADGTLKPV DEKEEVVAAE VGWMTSVKDW AGVMISAQTL TGRVLVVLVF 60
ALSIGALVIY FIDSSNPIES CQNFYKDFTL QIDMAFNVFF LLYFGLRFIA ANDKLWFWLE 120
VNSVVDFFTV PPVFVSVYLN RSWLGLRFLR ALRLIQFSEI LQFLNILKTS NSIKLVNLLS 180
IFISTWLTAA GFIHLVENSG DPWENFQNNQ ALTYWECVYL LMVTMSTVGY GDVYAKTTLG 240
RLFMVFFILG GLAMFARYVP EIAALILNRN KFGGTFNKHG GRKHIVVCGH ITLESVSNFL 300
KDFLHKDRDD VNVEIVFLHN ISPNLELEAL FKRHFTQVEF YQGSVLNPHD LARVKIESAD 360
ACLILANKYC ADPDAEDASN IMRVISIKNY HPKIRIITQM LQYHNKAHLL NIPSWNWKEG 420
DDAICLAELK LGFIAQSCLA QGLSTMLANL FSMRSFIKIE EDTWQKYYLE GVSNEMYTEY 480
LSSAFVGLSF PTVCELCFVK LKLLMIAIEY KSANRESRIL INPGNHLKIQ EGTLGFFIAS 540
DAKEVKRAFF YCKACHDDVT DPKRIKKCGC RRLEDEQPPT LSPKKKQRNG GMRNSPNTSP 600
KLMRHDPLLI PGNDQIDNMD SNVKKYDSTG MFHWCAPKEI EKVILTRSEA AMTVLSGHVV 660
VCIFGDVSSA LIGLRNLVMP LRASNFHYHE LKHIVFVGSI EYLKREWETL HNFPKVSILP 720
GTPLSRADLR AVNINLCDMC VILSANQNNI DDTSLQDKEC ILASLNIKSM QFDDSIGVLQ 780
ANSQGFTPPG MDRSSPDNSP VHGMLRQPSI TTGVNIPIIT ELVNDTNVQF LDQDDDDDPD 840
TELYLTQPFA CGTAFAVSVL DSLMSATYFN DNILTLIRTL VTGGATPELE ALIAEENALR 900
GGYSTPQTLA NRDRCRVAQL ALLDGPFADL GDGGCYGDLF CKALKTYNML CFGIYRLRDA 960
HLSTPSQCTK RYVITNPPYE FELVPTDLIF CLMQFDHNAG QSRASLSHSS HSSQSSSKKS 1020
SSVHSIPSTA NRPNRPKSRE SRDKQKYVQE ERL 1053 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0045211; C:postsynaptic membrane; IDA:MGI.
 GO:0043195; C:terminal bouton; IDA:MGI.
 GO:0008076; C:voltage-gated potassium channel complex; IGI:MGI.
 GO:0060072; F:large conductance calcium-activated potassium channel activity; IDA:MGI.
 GO:0005249; F:voltage-gated potassium channel activity; IDA:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0042491; P:auditory receptor cell differentiation; IMP:MGI.
 GO:0048469; P:cell maturation; IMP:MGI.
 GO:0060082; P:eye blink reflex; IMP:MGI.
 GO:0045475; P:locomotor rhythm; IMP:MGI.
 GO:0045794; P:negative regulation of cell volume; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0019228; P:regulation of action potential in neuron; IMP:MGI.
 GO:0032344; P:regulation of aldosterone metabolic process; IMP:MGI.
 GO:0060087; P:relaxation of vascular smooth muscle; IMP:MGI.
 GO:0001666; P:response to hypoxia; IDA:MGI.
 GO:0046541; P:saliva secretion; IGI:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0060083; P:smooth muscle contraction involved in micturition; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI. 
Interpro
 IPR024939; Ca-act_K_channel_Slo.
 IPR005821; Ion_trans_dom.
 IPR003091; K_chnl.
 IPR003929; K_chnl_Ca-activ_BK_asu.
 IPR016040; NAD(P)-bd_dom.
 IPR003148; RCK_N. 
Pfam
 PF03493; BK_channel_a
 PF00520; Ion_trans
 PF02254; TrkA_N 
SMART
  
PROSITE
  
PRINTS
 PR01449; BKCHANNELA.
 PR00169; KCHANNEL.