CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001131
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatase and actin regulator 2 
Protein Synonyms/Alias
  
Gene Name
 PHACTR2 
Gene Synonyms/Alias
 C6orf56; KIAA0680 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
548LEQRNILKQKNEEEEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 REPEAT 60 85 RPEL 1.
 REPEAT 477 502 RPEL 2.
 REPEAT 515 540 RPEL 3.
 REPEAT 553 578 RPEL 4.
 MOD_RES 522 522 Phosphoserine.  
Keyword
 Actin-binding; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Protein phosphatase inhibitor; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 634 AA 
Protein Sequence
MGQTSVSTLS PQPGSVDGLD KASIANSDGP TAGSQTPPFK RKGKLSTIGK IFKPWKWRKK 60
KTSDKFRETS AVLERKISTR QSREELIRRG VLKELPDQDG DVTVNFENSN GHMIPIGEES 120
TREENVVKSE EGNGSVSEKT PPLEEQAEDK KENTENHSET PAAPALPPSA PPKPRPKPKP 180
KKSPVPPKGA TAGASHKGDE VPPIKKNTKA PGKQAPVPPP KPASRNTTRE AAGSSHSKKT 240
TGSKASASPS TSSTSSRPKA SKETVSSKAG TVGTTKGKRK TDKQPITSHL SSDTTTSGTS 300
DLKGEPAETR VESFKLEQTV PGAEEQNTGK FKSMVPPPPV APAPSPLAPP LPLEDQCITA 360
SDTPVVLVSV GADLPVSALD PSQLLWAEEP TNRTTLYSGT GLSVNRENAK CFTTKEELGK 420
TVPQLLTPGL MGESSESFSA SEDEGHREYQ ANDSDSDGPI LYTDDEDEDE DEDGSGESAL 480
ASKIRRRDTL AIKLGNRPSK KELEDKNILQ RTSEEERQEI RQQIGTKLVR RLSQRPTTEE 540
LEQRNILKQK NEEEEQEAKM ELKRRLSRKL SLRPTVAELQ ARRILRFNEY VEVTDSPDYD 600
RRADKPWARL TPADKAAIRK ELNEFKSTEM EVHEESRQFT RFHRP 645 
Gene Ontology
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW. 
Interpro
 IPR004018; RPEL_repeat. 
Pfam
 PF02755; RPEL 
SMART
 SM00707; RPEL 
PROSITE
 PS51073; RPEL 
PRINTS