| Tag | Content |
|---|
| CPLM ID | CPLM-005180 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase gamma |
Protein Synonyms/Alias | Protein-tyrosine phosphatase gamma; R-PTP-gamma |
Gene Name | PTPRG |
Gene Synonyms/Alias | PTPG |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 802 | DMEAIPVKQFVKHIG | ubiquitination | [1] | | 806 | IPVKQFVKHIGELYS | ubiquitination | [1] | | 900 | IATQGPLKSTFEDFW | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Possesses tyrosine phosphatase activity. |
Sequence Annotation | DOMAIN 58 321 Alpha-carbonic anhydrase.
DOMAIN 346 443 Fibronectin type-III.
DOMAIN 848 1119 Tyrosine-protein phosphatase 1.
DOMAIN 1150 1410 Tyrosine-protein phosphatase 2.
REGION 1060 1066 Substrate binding (By similarity).
ACT_SITE 1060 1060 Phosphocysteine intermediate (By
BINDING 1028 1028 Substrate (By similarity).
BINDING 1104 1104 Substrate (By similarity).
MOD_RES 115 115 Phosphothreonine (By similarity).
MOD_RES 1182 1182 Phosphoserine.
CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
CARBOHYD 113 113 N-linked (GlcNAc...).
CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
CARBOHYD 359 359 N-linked (GlcNAc...) (Potential).
CARBOHYD 444 444 N-linked (GlcNAc...).
CARBOHYD 619 619 N-linked (GlcNAc...) (Potential).
CARBOHYD 631 631 N-linked (GlcNAc...) (Potential).
CARBOHYD 722 722 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1445 AA |
Protein Sequence | MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 60
AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 120
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 180
PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 240
LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 360
TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 420
FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 480
TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 540
AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 600
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 660
DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 720
KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRKCFQTAH FYVEDSSSPR 780
VVPNESIPII PIPDDMEAIP VKQFVKHIGE LYSNNQHGFS EDFEEVQRCT ADMNITAEHS 840
NHPENKHKNR YINILAYDHS RVKLRPLPGK DSKHSDYINA NYVDGYNKAK AYIATQGPLK 900
STFEDFWRMI WEQNTGIIVM ITNLVEKGRR KCDQYWPTEN SEEYGNIIVT LKSTKIHACY 960
TVRRFSIRNT KVKKGQKGNP KGRQNERVVI QYHYTQWPDM GVPEYALPVL TFVRRSSAAR 1020
MPETGPVLVH CSAGVGRTGT YIVIDSMLQQ IKDKSTVNVL GFLKHIRTQR NYLVQTEEQY 1080
IFIHDALLEA ILGKETEVSS NQLHSYVNSI LIPGVGGKTR LEKQFKLVTQ CNAKYVECFS 1140
AQKECNKEKN RNSSVVPSER ARVGLAPLPG MKGTDYINAS YIMGYYRSNE FIITQHPLPH 1200
TTKDFWRMIW DHNAQIIVML PDNQSLAEDE FVYWPSREES MNCEAFTVTL ISKDRLCLSN 1260
EEQIIIHDFI LEATQDDYVL EVRHFQCPKW PNPDAPISST FELINVIKEE ALTRDGPTIV 1320
HDEYGAVSAG MLCALTTLSQ QLENENAVDV FQVAKMINLM RPGVFTDIEQ YQFIYKAMLS 1380
LVSTKENGNG PMTVDKNGAV LIADESDPAE SMESLV 1416 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc. GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |