CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014017
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor HES-5 
Protein Synonyms/Alias
 Class B basic helix-loop-helix protein 38; bHLHb38; Hairy and enhancer of split 5 
Gene Name
 HES5 
Gene Synonyms/Alias
 BHLHB38 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
134AAPAKEPKAPGAAPPubiquitination[1]
Reference
 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266
Functional Description
 Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). 
Sequence Annotation
 DOMAIN 16 72 bHLH.
 DOMAIN 88 119 Orange.
 MOTIF 163 166 WRPW motif.  
Keyword
 Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 166 AA 
Protein Sequence
MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD 60
ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV QFLTLHAASD TQMKLLYHFQ 120
RPPAAPAAPA KEPKAPGAAP PPALSAKATA AAAAAHQPAC GLWRPW 166 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; NAS:UniProtKB.
 GO:0048708; P:astrocyte differentiation; ISS:UniProtKB.
 GO:0042491; P:auditory receptor cell differentiation; ISS:UniProtKB.
 GO:0042668; P:auditory receptor cell fate determination; IEA:Compara.
 GO:0043010; P:camera-type eye development; ISS:UniProtKB.
 GO:0051216; P:cartilage development; IDA:UniProtKB.
 GO:0007155; P:cell adhesion; ISS:UniProtKB.
 GO:0048469; P:cell maturation; ISS:UniProtKB.
 GO:0022010; P:central nervous system myelination; ISS:UniProtKB.
 GO:0072049; P:comma-shaped body morphogenesis; IEA:Compara.
 GO:0021861; P:forebrain radial glial cell differentiation; IEA:Compara.
 GO:0021781; P:glial cell fate commitment; ISS:UniProtKB.
 GO:0072282; P:metanephric nephron tubule morphogenesis; IEA:Compara.
 GO:0048712; P:negative regulation of astrocyte differentiation; ISS:UniProtKB.
 GO:2000978; P:negative regulation of forebrain neuron differentiation; IEA:Compara.
 GO:2000981; P:negative regulation of inner ear receptor cell differentiation; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
 GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:UniProtKB.
 GO:2000974; P:negative regulation of pro-B cell differentiation; ISS:UniProtKB.
 GO:2000737; P:negative regulation of stem cell differentiation; IMP:UniProtKB.
 GO:0021915; P:neural tube development; ISS:UniProtKB.
 GO:0097150; P:neuronal stem cell maintenance; IEP:UniProtKB.
 GO:0007219; P:Notch signaling pathway; IMP:UniProtKB.
 GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
 GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IGI:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.
 GO:0006461; P:protein complex assembly; ISS:UniProtKB.
 GO:0031641; P:regulation of myelination; ISS:UniProtKB.
 GO:0072050; P:S-shaped body morphogenesis; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
 GO:0072086; P:specification of loop of Henle identity; IEA:Compara.
 GO:0021537; P:telencephalon development; ISS:UniProtKB. 
Interpro
 IPR011598; bHLH_dom.
 IPR003650; Orange. 
Pfam
 PF07527; Hairy_orange
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH
 PS51054; ORANGE 
PRINTS