CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032063
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sec1 family domain-containing protein 1 
Protein Synonyms/Alias
 cDNA FLJ58612, highly similar to Sec1 family domain-containing protein 1 
Gene Name
 SCFD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139YDLTPVDKFWQKHKGacetylation[1]
139YDLTPVDKFWQKHKGubiquitination[2, 3, 4]
143PVDKFWQKHKGSPFPacetylation[1]
145DKFWQKHKGSPFPEVacetylation[1]
145DKFWQKHKGSPFPEVubiquitination[3]
210SLPELLEKKRLIDLHubiquitination[3, 5, 6]
251MSKTTLDKSLLDIISubiquitination[5]
309LNPLQYIKQWKAFTKubiquitination[2]
316KQWKAFTKMASAPASubiquitination[2, 3]
330SYGSTTTKPMGLLSRubiquitination[5, 6]
351QFVMEGVKNLVLKQQubiquitination[5]
356GVKNLVLKQQNLPVTubiquitination[3, 4, 5]
373LDNLMEMKSNPETDDubiquitination[3, 5, 6]
Reference
 [1] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 457 AA 
Protein Sequence
METVMDTIVD SLFCFFVTLG AVPIIRCSRG TAAEMVAVKL DKKLRENLRD ARNSLFTGDT 60
LGAGQFSFQR PLLVLVDRNI DLATPLHHTW TYQALVHDVL DFHLNRVNLE ESSGVENSPA 120
GARPKRKNKK SYDLTPVDKF WQKHKGSPFP EVAESVQQEL ESYRAQEDEV KRLKSIMGLE 180
GEDEGAISML SDNTAKLTSA VSSLPELLEK KRLIDLHTNV ATAVLEHIKA RKLDVYFEYE 240
EKIMSKTTLD KSLLDIISDP DAGTPEDKMR LFLIYYISTQ QAPSEADLEQ YKKALTDAGC 300
NLNPLQYIKQ WKAFTKMASA PASYGSTTTK PMGLLSRVMN TGSQFVMEGV KNLVLKQQNL 360
PVTRILDNLM EMKSNPETDD YRYFDPKMLR GNDSSVPRNK NPFQEAIVFV VGGGNYIEYQ 420
NLVDYIKGKQ GKHILYGCSE LFNATQFIKQ LSQLGQK 457 
Gene Ontology
 GO:0017119; C:Golgi transport complex; IEA:Compara.
 GO:0005798; C:Golgi-associated vesicle; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0006892; P:post-Golgi vesicle-mediated transport; IEA:Compara.
 GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:Compara.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS