CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042648
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heart- and neural crest derivatives-expressed protein 2 
Protein Synonyms/Alias
  
Gene Name
 HAND2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58VKEEKRKKELNEILKubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 92 AA 
Protein Sequence
XPNVPADTKL SKIKTLRLAT SYIAYLMDLL AKDDQNGEAE AFKAEIKKTD VKEEKRKKEL 60
NEILKSTVSS NDKKTKGRTG WPQHVWALEL KQ 92 
Gene Ontology
  
Interpro
 IPR011598; bHLH_dom. 
Pfam
 PF00010; HLH 
SMART
  
PROSITE
 PS50888; BHLH 
PRINTS