UniProt Accession

 B3KRH1_HUMAN; B3KRH1 

Genbank Protein ID

 AL109865; AK091574; CH471067 

Genbank Nucleotide ID

 BAG52383.1; EAW91187.1 

Protein Name

 E3 ubiquitin-protein ligase RING2 

Protein Synonyms/Alias

 Ring finger protein 2, isoform CRA_a; cDNA FLJ34255 fis, clone FCBBF5000353, highly similar to Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) 

Gene Name

 RNF2 

Gene Synonyms/Alias

 hCG_40894 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	LKNTMTTKECLHRFC	ubiquitination	[1, 2]
177	SAQTRYIKTSGNATV	ubiquitination	[3]
189	ATVDHLSKYLAVRLA	ubiquitination	[3]
248	LVSEKYWKVNKPMEL	ubiquitination	[3]
251	EKYWKVNKPMELYYA	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ligase; Metal-binding; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00097; zf-C3HC4 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS