UniProt Accession

 EAA2_MOUSE; P43006; O35877; O54686; O54687 

Genbank Protein ID

 U11763; D43796; U24699; U75372; U75373; AB007810; AB007811; AB007812 

Genbank Nucleotide ID

 AAA77673.1; BAA07854.1; AAA91643.1; AAB71737.1; AAB71738.1; BAA23770.1; BAA23771.1; BAA23772.1 

Protein Name

 Excitatory amino acid transporter 2 

Protein Synonyms/Alias

 GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 

Gene Name

 Slc1a2 

Gene Synonyms/Alias

 Eaat2; Glt1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	VSANNMPKQVEVRMH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. 

Sequence Annotation

 MOD_RES 493 493 Phosphotyrosine.
 MOD_RES 537 537 Phosphotyrosine.
 MOD_RES 562 562 Phosphoserine.
 LIPID 38 38 S-palmitoyl cysteine.
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 572 AA 

Protein Sequence

Gene Ontology

 GO:0030673; C:axolemma; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IC:MGI.
 GO:0015501; F:glutamate:sodium symporter activity; IDA:MGI.
 GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro.
 GO:0030534; P:adult behavior; IMP:MGI.
 GO:0031668; P:cellular response to extracellular stimulus; IMP:MGI.
 GO:0070779; P:D-aspartate import; IEA:Compara.
 GO:0051938; P:L-glutamate import; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0010259; P:multicellular organismal aging; IMP:MGI.
 GO:0046326; P:positive regulation of glucose import; IMP:MGI.
 GO:0043200; P:response to amino acid stimulus; IMP:MGI.
 GO:0042493; P:response to drug; IMP:MGI.
 GO:0009611; P:response to wounding; IMP:MGI.
 GO:0021537; P:telencephalon development; IMP:MGI.
 GO:0007632; P:visual behavior; IMP:MGI. 

Interpro

 IPR001991; Na-dicarboxylate_symporter.
 IPR018107; Na-dicarboxylate_symporter_CS. 

Pfam

 PF00375; SDF 

SMART

  

PROSITE

 PS00713; NA_DICARBOXYL_SYMP_1
 PS00714; NA_DICARBOXYL_SYMP_2 

PRINTS

 PR00173; EDTRNSPORT.