CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium channel protein type 4 subunit alpha 
Protein Synonyms/Alias
 Sodium channel, voltage-gated, type IV, alpha 
Gene Name
 Scn4a 
Gene Synonyms/Alias
 mCG_2873 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
480QEELEKAKAAQALEGubiquitination[1]
1706FMAANPSKVSYEPITubiquitination[1]
1717EPITTTLKRKQEEVCubiquitination[1]
1742HLLQRSVKQASYMYRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1841 AA 
Protein Sequence
MASSSLPTLV PPGPHCLRPF TPESLAAIEQ RAMEEEARLQ RNKQMEIEEP ERKPRSDLEA 60
GKNLPLIYGD PPPEVIGVPL EDLDPYYSDK KTFIVLNKGK AIFRFSATPA LYMLSPFSIV 120
RRVAIKVLIH ALFSMFIMIT ILTNCVFMTM SNPPSWSKDV EYTFTGIYTF ESLIKMLARG 180
FCIDDFTFLR DPWNWLDFSV ITMAYVTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV 240
GALIQSVKKL SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPPMNDT NTTWYGNDTW 300
YGNDTWYGND TWYGNDTWNS QESWVSNSTF DWEAYINDEG NFYFLEGSND ALLCGNSSDA 360
GHCPEGYECM KAGRNPNYGY TSYDTFSWAF LALFRLMTQD YWENLFQLTL RAAGKTYMIF 420
FVVIIFLGSF YLINLILAVV AMAYAEQNEA TLAEDQEKEE EFQQMLEKFK KHQEELEKAK 480
AAQALEGGEE ADGDPTHSKD CNGSLDTSGE KGPPRPSCSA ESAISDAMEE LEEAHQKCPP 540
WWYKCAHKVL IWNCCAPWVK FKHIILLIVM DPFVDLGITI CIVLNTLFMA MEHYPMTEHF 600
DNVLSVGNLV FTGIFTAEMV LKLIAMDPYE YFQQGWNIFD SFIVTLSLVE LGLANVQGLS 660
VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY 720
KECVCKIASD CSLPRWHMHD FFHSFLIVFR ILCGEWIETM WDCMEVAGQA MCLTVFLMVM 780
VIGNLVVLNL FLALLLSSFS ADSLAASDED GEMNNLQIAI GRIKWGIAFA KTFLLGLLHG 840
KILSLKDIML SLGEPGGAGE NGESPPEDEK KEPPPEDGNK ELKDNHILNH VGLTDGPRSS 900
IEMDHLNFIN NPYLTIHVPI ASEESDLEMP TEEETDTFSE PEDIKKPLQP LYDGNSSVCS 960
TADYKPPEED PEEQAEENPE GELPEECFTE ACVKRCPCLY VDISQGRGKM WWTLRRACFK 1020
IVEHNWFETF IVFMILLSSG ALAFEDIYIE QRRVIQTILE YADKVFTYIF ILEMLLKWVA 1080
YGFKVYFTNA WCWLDFLIVD VSIISLVANW LGYSELGPIK SLRTLRALRP LRALSRFEGM 1140
RVVVNALLGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YYCINTTTSE RFDISVVNNK 1200
SECESLMYTG QVRWMNVKVN YDNVGLGYLS LLQVATFKGW MDIMYAAVDS REKEEQPDYE 1260
VNLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GKDIFMTEEQ KKYYNAMKKL 1320
GSKKPQKPIP RPQNKIQGMV YDFVTKQVFD ISIMILICLN MVTMMVETDD QSQLKVDILY 1380
NINMVFIIVF TGECVLKMFA LRHYYFTIGW NIFDFVVVIL SIVGLALSDL IQKYFVSPTL 1440
FRVIRLARIG RVLRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY SIFGMSNFAY 1500
VKKESGIDDM FNFETFGNSI ICLFEITTSA GWDGLLNPIL NSGPPDCDPT LENPGTNIKG 1560
DCGNPSIGIC FFCSYIIISF LIVVNMYIAI ILENFNVATE ESSEPLCEDD FEMFYETWEK 1620
FDPDATQFID YSRLSDFVDT LQEPLKIAKP NKIKLITLDL PMVPGDKIHC LDILFALTKE 1680
VLGDSGEMDA LKQTMEEKFM AANPSKVSYE PITTTLKRKQ EEVCAIKIQR AYRRHLLQRS 1740
VKQASYMYRH SQEGNGDGAP EKEGLLANTM NKMYGSEKED NGVQSQGEKE KDSTEDAGPT 1800
TEVTAPSSSD TALTPPPPSP PPPSSPPQGQ TVRPGVKESL V 1841 
Gene Ontology
 GO:0001518; C:voltage-gated sodium channel complex; IC:MGI.
 GO:0005248; F:voltage-gated sodium channel activity; IDA:MGI. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR008052; Na_channel_a4su.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ 
PRINTS
 PR00170; NACHANNEL.
 PR01665; NACHANNEL4.