UniProt Accession

 IRK11_MOUSE; Q61743; Q9QX21 

Genbank Protein ID

 D50581; U73626; AF037313; BC052731; BC057006 

Genbank Nucleotide ID

 BAA09130.1; AAB17355.1; AAD02096.1; AAH52731.1; AAH57006.1 

Protein Name

 ATP-sensitive inward rectifier potassium channel 11 

Protein Synonyms/Alias

 Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11 

Gene Name

 Kcnj11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MLSRKGIIPEEY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). 

Sequence Annotation

 MOTIF 130 135 Selectivity filter (By similarity).
 MOD_RES 341 341 Phosphothreonine; by MAPK1 (By
 MOD_RES 385 385 Phosphoserine; by MAPK1 (By similarity).  

Keyword

 Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 390 AA 

Protein Sequence

Gene Ontology

 GO:0008282; C:ATP-sensitive potassium channel complex; IDA:BHF-UCL.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030315; C:T-tubule; IDA:BHF-UCL.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:Compara.
 GO:0005524; F:ATP binding; IDA:BHF-UCL.
 GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IDA:BHF-UCL.
 GO:0030955; F:potassium ion binding; IC:BHF-UCL.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0046676; P:negative regulation of insulin secretion; IEA:Compara.
 GO:0050877; P:neurological system process; IEA:Compara.
 GO:0010107; P:potassium ion import; IDA:BHF-UCL.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0033198; P:response to ATP; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003279; K_chnl_inward-rec_Kir6.2.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 

Pfam

 PF01007; IRK 

SMART

  

PROSITE

  

PRINTS

 PR01332; KIR62CHANNEL.
 PR01320; KIRCHANNEL.