| Tag | Content |
|---|
| CPLM ID | CPLM-005258 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carboxylesterase 1C |
Protein Synonyms/Alias | Liver carboxylesterase N; Lung surfactant convertase; PES-N |
Gene Name | Ces1c |
Gene Synonyms/Alias | Es1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 78 | AEPWSFVKNATSYPP | acetylation | [1] |
|
Reference | [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. J Biol Chem. 2013 Jul 17;. [ PMID: 23864654] |
Functional Description | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. |
Sequence Annotation | MOTIF 551 554 Prevents secretion from ER (Potential).
ACT_SITE 221 221 Acyl-ester intermediate (By similarity).
ACT_SITE 342 342 Charge relay system (By similarity).
ACT_SITE 455 455 Charge relay system (By similarity).
CARBOHYD 79 79 N-linked (GlcNAc...).
CARBOHYD 274 274 N-linked (GlcNAc...).
CARBOHYD 304 304 N-linked (GlcNAc...).
CARBOHYD 377 377 N-linked (GlcNAc...).
CARBOHYD 478 478 N-linked (GlcNAc...) (Potential).
DISULFID 87 116 By similarity.
DISULFID 273 284 By similarity. |
Keyword | Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 554 AA |
Protein Sequence | MWLHALVWAS LAVCPILGHS LLPPVVDTTQ GKVLGKYISL EGFEQPVAVF LGVPFAKPPL 60
GSLRFAPPQP AEPWSFVKNA TSYPPMCSQD AGWAKILSDM FSTEKEILPL KISEDCLYLN 120
IYSPADLTKS SQLPVMVWIH GGGLVIGGAS PYNGLALSAH ENVVVVTIQY RLGIWGLFST 180
GDEHSPGNWA HLDQLAALRW VQDNIANFGG NPDSVTIFGE SSGGISVSVL VLSPLGKDLF 240
HRAISESGVV INTNVGKKNI QAVNEIIATL SQCNDTSSAA MVQCLRQKTE SELLEISGKL 300
VQYNISLSTM IDGVVLPKAP EEILAEKSFN TVPYIVGFNK QEFGWIIPMM LQNLLPEGKM 360
NEETASLLLR RFHSELNISE SMIPAVIEQY LRGVDDPAKK SELILDMFGD IFFGIPAVLL 420
SRSLRDAGVS TYMYEFRYRP SFVSDKRPQT VEGDHGDEIF FVFGAPLLKE GASEEETNLS 480
KMVMKFWANF ARNGNPNGEG LPHWPEYDEQ EGYLQIGATT QQAQRLKAEE VAFWTELLAK 540
NPPETDPTEH TEHK 554 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0005615; C:extracellular space; IDA:MGI. GO:0004091; F:carboxylesterase activity; IDA:MGI. GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC. GO:0080032; F:methyl jasmonate esterase activity; IEA:EC. GO:0080031; F:methyl salicylate esterase activity; IEA:EC. GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |