CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029961
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hepatocyte growth factor-regulated tyrosine kinase substrate 
Protein Synonyms/Alias
  
Gene Name
 Hgs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
471YYEGLQDKLAQIRDAubiquitination[1]
511RQIQLAQKLEIMRQKubiquitination[1]
519LEIMRQKKQEYLEVQacetylation[2]
519LEIMRQKKQEYLEVQubiquitination[1]
549QMRLEQQKQTVQMRAacetylation[3]
549QMRLEQQKQTVQMRAsuccinylation[3]
549QMRLEQQKQTVQMRAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 766 AA 
Protein Sequence
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 120
NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVVTRKH 180
HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN KKAEGKASST TELPPEYLTS 240
PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERM RQKTTYTAHP KAEPTPLASS 300
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ 360
PGEGHTAPNS MAEAPLPETD SQPITPCSGP FSEYQNGESE ESHEQFLKAL QNAVSTFVNR 420
MKSNHMRGRS ITNDSAVLSL FQSINTMHPQ LLELLNQLDE RRLYYEGLQD KLAQIRDARG 480
ALSALREEHR EKLRRAAEEA ERQRQIQLAQ KLEIMRQKKQ EYLEVQRQLA IQRLQEQEKE 540
RQMRLEQQKQ TVQMRAQMPA FPLPYAQAGY AHGWGCTLPA LRPNQLPCHL QPSRLSRGLS 600
DAWCVYEPAS PSHWPLPQHA WHNSRSQHGQ RLHVPNRCPW GTGSPSGPGR AHHQSCLLLL 660
PAHTNPRLPE RGFSGPTEPP SHLTASTDQQ HRLHGEPANV HGLPAVQYAE SHDRPSRAGC 720
VSASPAALHP RAAAPVPADG PQHRPSPAAT PCGPASAYTG TASTGQ 766 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016197; P:endosomal transport; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0009966; P:regulation of signal transduction; IEA:InterPro. 
Interpro
 IPR008942; ENTH_VHS.
 IPR027426; HGS.
 IPR024641; HRS_helical.
 IPR017073; Ubi-bd_Hrs_VPS27.
 IPR003903; Ubiquitin-int_motif.
 IPR002014; VHS.
 IPR018205; VHS_subgr.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF12210; Hrs_helical
 PF00790; VHS 
SMART
 SM00064; FYVE
 SM00726; UIM
 SM00288; VHS 
PROSITE
 PS50330; UIM
 PS50179; VHS
 PS50178; ZF_FYVE 
PRINTS