| Tag | Content |
|---|
| CPLM ID | CPLM-004758 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Formate hydrogenlyase transcriptional activator |
Protein Synonyms/Alias | |
Gene Name | fhlA |
Gene Synonyms/Alias | b2731; JW2701 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | DDRPWSEKEFNRLQT | acetylation | [1] | | 564 | EDIPLLAKAFTFKIA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. |
Sequence Annotation | DOMAIN 202 344 GAF.
DOMAIN 381 610 Sigma-54 factor interaction.
NP_BIND 409 416 ATP (Potential).
NP_BIND 472 481 ATP (Potential).
DNA_BIND 663 682 H-T-H motif (By similarity). |
Keyword | Activator; ATP-binding; Complete proteome; DNA-binding; Nucleotide-binding; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 692 AA |
Protein Sequence | MSYTPMSDLG QQGLFDITRT LLQQPDLASL CEALSQLVKR SALADNAAIV LWQAQTQRAS 60
YYASREKDTP IKYEDETVLA HGPVRSILSR PDTLHCSYEE FCETWPQLDA GGLYPKFGHY 120
CLMPLAAEGH IFGGCEFIRY DDRPWSEKEF NRLQTFTQIV SVVTEQIQSR VVNNVDYELL 180
CRERDNFRIL VAITNAVLSR LDMDELVSEV AKEIHYYFDI DDISIVLRSH RKNKLNIYST 240
HYLDKQHPAH EQSEVDEAGT LTERVFKSKE MLLINLHERD DLAPYERMLF DTWGNQIQTL 300
CLLPLMSGDT MLGVLKLAQC EEKVFTTTNL NLLRQIAERV AIAVDNALAY QEIHRLKERL 360
VDENLALTEQ LNNVDSEFGE IIGRSEAMYS VLKQVEMVAQ SDSTVLILGE TGTGKELIAR 420
AIHNLSGRNN RRMVKMNCAA MPAGLLESDL FGHERGAFTG ASAQRIGRFE LADKSSLFLD 480
EVGDMPLELQ PKLLRVLQEQ EFERLGSNKI IQTDVRLIAA TNRDLKKMVA DREFRSDLYY 540
RLNVFPIHLP PLRERPEDIP LLAKAFTFKI ARRLGRNIDS IPAETLRTLS NMEWPGNVRE 600
LENVIERAVL LTRGNVLQLS LPDIVLPEPE TPPAATVVAL EGEDEYQLIV RVLKETNGVV 660
AGPKGAAQRL GLKRTTLLSR MKRLGIDKSA LI 692 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IGI:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |