CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029859
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Presenilin 2 (Alzheimer disease 4), isoform CRA_b 
Protein Synonyms/Alias
 Presenilin-2 CTF subunit 
Gene Name
 PSEN2 
Gene Synonyms/Alias
 hCG_15757 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115LEEELTLKYGAKHVIubiquitination[1]
148SVRFYTEKNGQLIYTubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 481 AA 
Protein Sequence
MLAGTVRFAR HCLKFFPAQK PACVDFGASR GRAMLTFMAS DSEEEVCDER TSLMSAESPT 60
PRSCQEGRQG PEDGENTAQW RSQENEEDGE EDPDRYVCSG VPGRPPGLEE ELTLKYGAKH 120
VIMLFVPVTL CMIVVVATIK SVRFYTEKNG QLIYTPFTED TPSVGQRLLN SVLNTLIMIS 180
VIVVMTIFLV VLYKYRCYKF IHGWLIMSSL MLLFLFTYIY LGEVLKTYNV AMDYPTLLLT 240
VWNFGAVGMV CIHWKGPLVL QQAYLIMISA LMALVFIKYL PEWSAWVILG AISVYDLVAV 300
LCPKGPLRML VETAQERNEP IFPALIYSSA MVWTVGMAKL DPSSQGALQL PYDPEMEEDS 360
YDSFGEPSYP EVFEPPLTGY PGEELEEEEE RGVKLGLGDF IFYSVLVGKA AATGSGDWNT 420
TLACFVAILI GLCLTLLLLA VFKKALPALP ISITFGLIFY FSTDNLVRPF MDTLASHQLY 480
I 481 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001493; Pept_A22A_PS2.
 IPR006639; Peptidase_A22.
 IPR001108; Peptidase_A22A. 
Pfam
 PF01080; Presenilin 
SMART
 SM00730; PSN 
PROSITE
  
PRINTS
 PR01072; PRESENILIN.
 PR01074; PRESENILIN2.