UniProt Accession

 SML1_YEAST; Q04964; D6VZB6 

Genbank Protein ID

 Z46729; AY557961; BK006946 

Genbank Nucleotide ID

 CAA86717.1; AAS56287.1; DAA09840.1 

Protein Name

 Ribonucleotide reductase inhibitor protein SML1 

Protein Synonyms/Alias

  

Gene Name

 SML1 

Gene Synonyms/Alias

 YML058W; YM9958.04 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
91	KFGSGELKSMFNQGK	ubiquitination	[1]
98	KSMFNQGKVEEMDF*	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Strong inhibitor of ribonucleotide reductase (RNR1) and is involved in regulating dNTP production. 

Sequence Annotation

 MOD_RES 56 56 Phosphoserine; by DUN1.
 MOD_RES 58 58 Phosphoserine; by DUN1.
 MOD_RES 60 60 Phosphoserine; by DUN1.
 DISULFID 14 14 Interchain.  

Keyword

 Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; DNA damage; DNA replication inhibitor; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 104 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004857; F:enzyme inhibitor activity; IDA:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0007005; P:mitochondrion organization; IMP:SGD.
 GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IMP:SGD. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS